ArticleDiabetes care2015
Associations Between Prediabetes, by Three Different Diagnostic Criteria, and Incident CVD Differ in South Asians and Europeans.
Article in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Identification of pre-diabetes subphenotypes for type 2 diabetes, related vascular complications and mortality.BMJ open diabetes research & care · 2025Article
- Prediabetes is associated with elevated risk of clinical outcomes even without progression to diabetes.Diabetologia · 2025Article
- Green tea consumption and incidence of cardiovascular disease in type 2 diabetic patients with overweight/obesity: a community-based cohort study.Archives of public health = Archives belges de sante publique · 2024Article
- Changes in fasting blood glucose status and incidence of cardiovascular disease: The China-PAR project.Journal of diabetes · 2023Article
- The role of age on the risk relationship between prediabetes and major morbidities and mortality: Analysis of the Hong Kong diabetes surveillance database of 2 million Chinese adults.The Lancet regional health. Western Pacific · 2023Article
- Article
- Association between the triglyceride-glucose index and severity of coronary artery disease.Cardiovascular diabetology · 2022Article
- Global disease burden of stroke attributable to high fasting plasma glucose in 204 countries and territories from 1990 to 2019: An analysis of the Global Burden of Disease Study.Journal of diabetes · 2022Article
- Cardiorenal Risk Profiles Among Data-Driven Type 2 Diabetes Sub-Phenotypes: AFrontiers in endocrinology · 2022Article
- Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations.Scientific reports · 2021Article
- Prediabetes, Diabetes, and the Risk of All-Cause and Cause-Specific Mortality in a Japanese Working Population: Japan Epidemiology Collaboration on Occupational Health Study.Diabetes care · 2021Article
- Cohort Profile Update: Southall and Brent Revisited (SABRE) study: a UK population-based comparison of cardiovascular disease and diabetes in people of European, South Asian and African Caribbean heritage.International journal of epidemiology · 2020Article
- Association of Prediabetes With CKD Progression and Adverse Cardiovascular Outcomes: An Analysis of the CRIC Study.The Journal of clinical endocrinology and metabolism · 2020Article
- Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population.BMC endocrine disorders · 2019Article
- Cardiometabolic risk factors in Thai individuals with prediabetes treated in a high-risk, prevention clinic: Unexpected relationship between high-density lipoprotein cholesterol and glycemia in men.Journal of diabetes investigation · 2019Article
- Prediabetes in Colombia: Expert Consensus.Colombia medica (Cali, Colombia) · 2017Review
- Can Cardiovascular Epidemiology and Clinical Trials Close the Risk Management Gap Between Diabetes and Prediabetes?Current diabetes reports · 2017Review
- Comparative prognostic performance of definitions of prediabetes: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study.The lancet. Diabetes & endocrinology · 2017Article
- Noncommunicable disease in rural India: Are we seriously underestimating the risk? The Nallampatti noncommunicable disease study.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe examined longitudinal associations between prediabetes and cardiovascular disease (CVD) (coronary heart disease [CHD] and stroke) in Europeans and South Asians. RESEARCH DESIGN AND
methodsThis was a U.K. cohort study of 1,336 Europeans and 1,139 South Asians, aged 40-69 years at baseline (1988-1991). Assessment included blood pressure, blood tests, anthropometry, and questionnaires. Prediabetes was determined by OGTT or HbA1c, using either International Expert Committee (IEC) (HbA1c 6.0-6.5% [42-48 mmol/mol]) or American Diabetes Association (ADA) (HbA1c 5.7-6.5% [39-48 mmol/mol]) cut points. Incident CHD and stroke were established at 20 years from death certification, hospital admission, primary care record review, and participant report.
resultsCompared with normoglycemic individuals, IEC-defined prediabetes was related to both CHD and CVD risk in Europeans but not South Asians (subhazard ratio for CHD 1.68 [95% CI 1.19, 2.38] vs. 1.00 [0.75, 1.33], ethnicity interaction P = 0.008, and for CVD 1.49 [1.08, 2.07] vs. 1.03 [0.78, 1.36], ethnicity interaction P = 0.04). Conversely, IEC-defined prediabetes was associated with stroke risk in South Asians but not Europeans (1.73 [1.03, 2.90] vs. 0.85 [0.44, 1.64], ethnicity interaction P = 0.11). Risks were adjusted for age, sex, smoking, total-to-HDL cholesterol ratio, waist-to-hip ratio, systolic blood pressure, and antihypertensive use. Associations were weaker for OGTT or ADA-defined prediabetes. Conversion from prediabetes to diabetes was greater in South Asians, but accounting for time to conversion did not account for these ethnic differences.
conclusionsAssociations between prediabetes and CVD differed by prediabetes diagnostic criterion, type of CVD, and ethnicity, with associations being present for overall CVD in Europeans but not South Asians. Substantiation of these findings and investigation of potential explanations are required.
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