Evidence map›Paper›PMID 26485933›Full record

ArticleJournal of biomedical nanotechnology2015

UVB Dependence of Quantum Dot Reactive Oxygen Species Generation in Common Skin Cell Models.

Luke J Mortensen, Renea Faulknor, Supriya Ravichandran, Hong Zheng, Lisa A DeLouise

Open access · greenAbstract read
In one paragraph

Article in Journal of biomedical nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity.Advances in experimental medicine and biology · 2017
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Luke J Mortensen
Renea Faulknor
Supriya Ravichandran
Hong Zheng
Lisa A DeLouise
University of Rochester · US

Funding

Quantifying Risk Factors for Nanoparticle Contact with UVB Exposed SkinR01ES021492 · NIEHS · UNIVERSITY OF ROCHESTER · PI DELOUISE, LISA A · 2012 to 2022
$3.5M
Porous Silicon Optical Sensor for Candida DetectionK25AI060884 · NIAID · UNIVERSITY OF ROCHESTER · PI DELOUISE, LISA A · 2005 to 2009
$620k
NIAID NIH HHS K25 AI060884NIAID NIH HHS K25AI060884NIEHS NIH HHS R01 ES021492
6 · The paper itself

Abstract

Studies have shown that UVB can slightly increase the penetration of nanoparticles through skin and significantly alter skin cell biology, thus it is important to understand if and how UVB may impact subsequent nanoparticle skin cell interactions. The research presented herein evaluates the effect of UVB on quantum dot (QD) uptake and reactive oxygen species (ROS) generation in primary keratinocytes, primary melanocytes, and related cell lines. QD exposure induced cell type dependent ROS responses increased by pre-exposing cells to UVB and correlated with the level of QD uptake. Our results suggest that keratinocytes may be at greater risk for QD induced ROS generation than melanocytes, and raise awareness about the differential cellular effects that topically applied nanomaterials may have on UVB exposed skin.

Indexed as

Quantum DotsCell LineHumansKeratinocytesMaterials TestingRadiation DosageReactive Oxygen SpeciesSkinSkin AbsorptionUltraviolet RaysReactive Oxygen Species

Identifiers

PMID26485933
PMCPMC4625909
OpenAlexW1777315466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.