ArticleEmerging infectious diseases2015
Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010-2013.
Article in Emerging infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Prevalence ofHuman vaccines & immunotherapeutics · 2024Pooled it
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- Serotype distribution and antimicrobial susceptibility ofFrontiers in microbiology · 2024Article
- Serotypes and Antibiotic Resistance ofPathogens (Basel, Switzerland) · 2023Article
- Pilus ofFrontiers in cellular and infection microbiology · 2023Review
- Burden of illness associated with pneumococcal infections in Japan - a targeted literature review.Journal of market access & health policy · 2022Review
- Genotypic and phenotypic characteristics of Streptococcus pneumoniae from community-acquired pneumonia patients and healthy asymptomatic participants in Sichuan province, China.BMC infectious diseases · 2021Article
- Interrupted time-series analyses of routine vaccination program for elderly pneumonia patients in Japan; an ecological study using aggregated nationwide inpatient data.Human vaccines & immunotherapeutics · 2021Article
- Streptococcus pneumoniae serotype 3 genotypes in invasive isolates from Colombia.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Hemophagocytic lymphohistiocytosis complicating invasive pneumococcal disease: a pediatric case report.BMC pediatrics · 2020Article
- Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients.BMC infectious diseases · 2019Observational
- Epidemiological and clinical features of invasive pneumococcal disease caused by serotype 12F in adults, Japan.PloS one · 2019Article
- Preventive effects of pneumococcal and influenza vaccines on community-acquired pneumonia in older individuals in Japan: a case-control study.Human vaccines & immunotherapeutics · 2019Article
- Microbiome as a tool and a target in the effort to address antimicrobial resistance.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010-2017.Emerging infectious diseases · 2018Article
- Genome Evolution to Penicillin Resistance in Serotype 3 Streptococcus pneumoniae by Capsular Switching.Antimicrobial agents and chemotherapy · 2017Article
- Invasive pneumococcal infection due to serotype 15A after the pneumococcal conjugate vaccine implementation in Turkey.Human vaccines & immunotherapeutics · 2017Article
- Discovery of Novel Pneumococcal Serotype 35D, a Natural WciG-Deficient Variant of Serotype 35B.Journal of clinical microbiology · 2017Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After 7-valent pneumococcal conjugate vaccine (PCV) for children was introduced in Japan in November 2010, we examined changes in Streptococcus pneumoniae serotypes and in genetic antimicrobial drug resistance of isolates from adults with invasive pneumococcal diseases. During April 2010-March 2013, a total of 715 isolates were collected from adults with invasive pneumococcal diseases. Seven-valent PCV serotypes in adults decreased from 43.3% to 23.8%, most noticeably for serotype 6B. Concomitantly, 23-valent pneumococcal polysaccharide vaccine (PPSV23) serotypes decreased from 82.2% to 72.2%; non-PPSV23 serotypes increased from 13.8% to 25.1%. Parallel with serotype changes, genotypic penicillin-resistant S. pneumoniae decreased from 32.4% to 21.1%, and 6 non-PPSV23 serotypes emerged (6D, 15A, 15C, 16F, 23A, and 35B). Respective vaccine coverage rates for 13-valent PCV and PPSV23 differed by disease: 73.9% and 84.3% for patients with pneumonia, 56.4% and 69.2% for patients with bacteremia and sepsis, and 45.7% and 69.3% for patients with meningitis.
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