ArticleRadiology2016
Adverse Left Ventricular Remodeling and Age Assessed with Cardiac MR Imaging: The Multi-Ethnic Study of Atherosclerosis.
Open access · greenAbstract readMulticenter Study
In one paragraph
Article in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
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Who cites it
48 citing papers in PubMed, 100 citations in OpenAlex.
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- Associations of Accelerometer-Determined Sedentary and Physical Activity Behaviors with Heart Failure Biomarkers during Midlife: CARDIA Study.Medicine and science in sports and exercise · 2026Article
- Association Between Lipoprotein(a) and Cardiac Remodeling Across Race and Ethnicity in the Multi-Ethnic Study of Atherosclerosis.Circulation. Population health and outcomes · 2026Article
- Sex-specific structural and functional cardiac remodeling during healthy aging assessed by cardiovascular magnetic resonance.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Relationship between left ventricular shape and cardiovascular risk factors: comparison between the Multi-Ethnic Study of Atherosclerosis and UK Biobank.Heart (British Cardiac Society) · 2025Article
- Lung structure and longitudinal change in cardiac structure and function: the MESA COPD Study.The European respiratory journal · 2024Article
- CMR to characterize myocardial structure and function in heart failure with preserved left ventricular ejection fraction.European heart journal. Cardiovascular Imaging · 2024Review
- CHeart: A Conditional Spatio-Temporal Generative Model for Cardiac Anatomy.IEEE transactions on medical imaging · 2024Article
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Phenotyping heart failure by cardiac magnetic resonance imaging of cardiac macro- and microscopic structure: state of the art review.European heart journal. Cardiovascular Imaging · 2023Review
- Hepatocyte Growth Factor and 10-Year Change in Left Ventricular Structure: The Multi-Ethnic Study of Atherosclerosis (MESA).CJC open · 2023Article
- The Relationship between Extracellular Volume Compartments and Matrix Metalloproteinases-2 in Left Ventricular Remodeling after Myocardial Infarction.Arquivos brasileiros de cardiologia · 2022Article
- Myocardial fibrosis by T1 mapping magnetic resonance imaging predicts incident cardiovascular events and all-cause mortality: the Multi-Ethnic Study of Atherosclerosis.European heart journal. Cardiovascular Imaging · 2022Article
- Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV.BMC cardiovascular disorders · 2022Article
- Association of soluble Flt-1 with heart failure and cardiac morphology: The MESA angiogenesis study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
- Impact of cardiovascular risk factors on myocardial work-insights from the STAAB cohort study.Journal of human hypertension · 2022Article
- Association of changes in the infarct and remote zone myocardial tissue with cardiac remodeling after myocardial infarction: a T1 and T2 mapping study.The international journal of cardiovascular imaging · 2022Article
- Pre-diagnostic predictors of mortality in patients with heart failure: The multi-ethnic study of atherosclerosis.Frontiers in cardiovascular medicine · 2022Article
- Long-Lasting Myocardial and Skeletal Muscle Damage Evidenced by Serial CMR During the First Year in COVID-19 Patients From the First Wave.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
10 authors at 4 institutions in 1 country.
John EngFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
Robyn L McClellandFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
Antoinette S GomesFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
W Gregory HundleyFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
Susan ChengFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
Colin O WuFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
J Jeffrey CarrFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
Steven SheaFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
David A BluemkeFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
Joao A C LimaFrom the Russell H. Morgan Department of Radiology and Radiological Science (J.E.) and Division of Cardiology, Department of Medicine (J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Department of Biostatistics, University of Washington, Seattle, Wash (R.L.M.); Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, Calif (A.S.G.); Division of Cardiology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (W.G.H.); Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass (S.C.); Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Md (C.O.W.); Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tenn (J.J.C.); Departments of Medicine and Epidemiology, Columbia University, New York, NY (S.S.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (D.A.B.).
Johns Hopkins Medicine · USJohns Hopkins University · USUniversity of California, Los Angeles · USUniversity of Washington · US
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MMolecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0MCigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0MAdjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3MSUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758kMyocardial and Arterial Aging: Spectrum, Correlates, and PrognosisR00HL107642 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHENG, SUSAN · 2014 to 2016
$747kSUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694kSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642kSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616kSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592kSUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511kNCATS NIH HHS UL1 TR000040NCRR NIH HHS UL1 RR025005NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R00 HL107642
Abstract
purposeTo evaluate age-related left ventricular (LV) remodeling during longitudinal observation of a large cohort of asymptomatic individuals who were free of clinical cardiovascular disease at baseline. MATERIALS AND
methodsThe applicable institutional review boards approved this study, and all participants gave informed consent. Cardiac magnetic resonance (MR) imaging was used to identify longitudinal changes in LV structure and function in 2935 participants who underwent baseline and follow-up cardiac MR imaging in the Multi-Ethnic Study of Atherosclerosis. Participants were free of clinical cardiovascular disease at baseline. Participants who experienced an incident coronary heart disease event were excluded. Data were analyzed with multivariable mixed-effects regression models in which the outcome was cardiac MR imaging measurement, and the covariates included follow-up time and cardiac risk factors.
resultsParticipants were aged 54-94 years at follow-up, and 53% of the participants were women. Median time between baseline and follow-up cardiac MR imaging was 9.4 years. Over this period, LV mass increased in men and decreased slightly in women (8.0 and -1.6 g per decade, respectively; P < .001). In both men and women, LV end-diastolic volume decreased (-9.8 and -13.3 mL per decade, respectively; P < .001), stroke volume decreased (-8.8 and -8.6 mL per decade, respectively; P < .001), and mass-to-volume ratio increased (0.14 and 0.11 g/mL per decade, respectively; P < .001). Change in LV mass was positively associated with systolic blood pressure and body mass index and negatively associated with treated hypertension and high-density lipoprotein cholesterol level. In men, the longitudinal LV mass increase was in contrast to a cross-sectional pattern of LV mass decrease.
conclusionAs patients age, the LV responds differently in its mass and volume between men and women, although both men and women experience increased concentric LV remodeling with age. In men, the opposition of longitudinal and cross-sectional changes in LV mass highlights the importance of longitudinal study.
Indexed as
Ventricular RemodelingAgedAged, 80 and overAge FactorsAtherosclerosisCardiac-Gated Imaging TechniquesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRisk FactorsUnited States
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