Evidence map›Paper›PMID 26485544›Full record

ArticleTranslational psychiatry2015

Genome-wide differential expression of synaptic long noncoding RNAs in autism spectrum disorder.

Y Wang, X Zhao, W Ju, M Flory, J Zhong, S Jiang, P Wang, X Dong, X Tao, Q Chen and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Synaptic effects of interleukin-6 on human iPSC-derived dopaminergic neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  14. Focus on your locus with a massively parallel reporter assay.Journal of neurodevelopmental disorders · 2022
    Review
  15. Review
  16. Emerging Role of Non-coding RNAs in Autism Spectrum Disorder.Journal of molecular neuroscience : MN · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Y WangDepartment of Child Health Care, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.
X ZhaoChinese Alliance of Translational Medicine for Maternal and Children's Health, Beijing, China.
W JuDepartment of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
M FloryDepartment of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
J ZhongStudent volunteer, Hunter College High School, New York, NY, USA.
S JiangDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
P WangChinese Alliance of Translational Medicine for Maternal and Children's Health, Beijing, China.
X DongDepartment of Child Health Care, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.
X TaoChinese Alliance of Translational Medicine for Maternal and Children's Health, Beijing, China.
Q ChenDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
C ShenChinese Alliance of Translational Medicine for Maternal and Children's Health, Beijing, China.
M ZhongDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Y YuDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
W T BrownDepartment of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
N ZhongDepartment of Child Health Care, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.
Peking University · CNNew York State Office for People With Developmental Disabilities · USShanghai Children's Hospital · CNNanfang Hospital · CNSouthern Medical University · CNHunter College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A genome-wide differential expression of long noncoding RNAs (lncRNAs) was identified in blood specimens of autism spectrum disorder (ASD). A total of 3929 lncRNAs were found to be differentially expressed in ASD peripheral leukocytes, including 2407 that were upregulated and 1522 that were downregulated. Simultaneously, 2591 messenger RNAs (mRNAs), including 1789 upregulated and 821 downregulated, were also identified in ASD leukocytes. Functional pathway analysis of these lncRNAs revealed neurological pathways of the synaptic vesicle cycling, long-term depression and long-term potentiation to be primarily involved. Thirteen synaptic lncRNAs, including nine upregulated and four downregulated, and 19 synaptic mRNAs, including 12 upregulated and seven downregulated, were identified as being differentially expressed in ASD. Our identification of differential expression of synaptic lncRNAs and mRNAs suggested that synaptic vesicle transportation and cycling are important for the delivery of synaptosomal protein(s) between presynaptic and postsynaptic membranes in ASD. Finding of 19 lncRNAs, which are the antisense, bi-directional and intergenic, of HOX genes may lead us to investigate the role of HOX genes involved in the development of ASD. Discovery of the lncRNAs of SHANK2-AS and BDNF-AS, the natural antisense of genes SHANK2 and BDNF, respectively, indicates that in addition to gene mutations, deregulation of lncRNAs on ASD-causing gene loci presents a new approach for exploring possible epigenetic mechanisms underlying ASD. Our study also opened a new avenue for exploring the use of lncRNA(s) as biomarker(s) for the early detection of ASD.

Indexed as

Autism Spectrum DisorderChild, PreschoolFemaleGenome-Wide Association StudyHumansMaleRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID26485544
PMCPMC4930123
OpenAlexW1767499284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.