ArticleMolecular pharmaceutics2015
Polymeric Micelles as Carriers for Nerve-Highlighting Fluorescent Probe Delivery.
Article in Molecular pharmaceutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Spatio-temporally modulated fluorescence imager for intraoperative nerve identification.Journal of biomedical optics · 2026Article
- Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging.Current opinion in chemical biology · 2023Review
- Dual probe difference specimen imaging for prostate cancer margin assessment.Journal of biomedical optics · 2023Article
- A clinically relevant formulation for direct administration of nerve specific fluorophores to mitigate iatrogenic nerve injury.Biomaterials · 2022Article
- A targeted combinatorial therapy for Ewing's sarcoma.Nanomedicine : nanotechnology, biology, and medicine · 2021Article
- Clinically translatable formulation strategies for systemic administration of nerve-specific probes.Advanced therapeutics · 2021Article
- Clinically relevant dual probe difference specimen imaging (DDSI) protocol for freshly resected breast cancer specimen staining.BMC cancer · 2021Article
- Diagnostic Performance of Receptor-Specific Surgical Specimen Staining Correlate with Receptor Expression Level.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Diagnostic performance of receptor-specific surgical specimen staining correlates with receptor expression level.Journal of biomedical optics · 2019Article
- Investigation of Oxazine and Rhodamine Derivatives as Peripheral Nerve Tissue Targeting Contrast Agent forProceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Nile Red derivatives enable improved ratiometric imaging for nerve-specific contrast.Journal of biomedical optics · 2018Article
- Direct Administration of Nerve-Specific Contrast to Improve Nerve Sparing Radical Prostatectomy.Theranostics · 2017Article
- Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery.Theranostics · 2017Article
- Rapid fluorescence imaging of spinal cord following epidural administration of a nerve-highlighting fluorophore.Theranostics · 2017Article
- Visualizing Oxazine 4 nerve-specific fluorescenceProceedings of SPIE--the International Society for Optical Engineering · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Nerve damage during surgery is a common morbidity experienced by patients that leaves them with chronic pain and/or loss of function. Currently, no clinically approved imaging technique exists to enhance nerve visualization in the operating room. Fluorescence image-guided surgery has gained in popularity and clinical acceptance over the past decade with a handful of imaging systems approved for clinical use. However, contrast agent development to complement these fluorescence-imaging systems has lagged behind with all currently approved fluorescent agents providing untargeted blood pool information. Nerve-specific fluorophores are known, however translations of these agents to the clinic has been complicated by their lipophilic nature, which necessitates specialized formulation strategies for successful systemic administration. To date the known nerve-specific fluorophores have only been demonstrated preclinically due to the necessity of a dimethyl sulfoxide containing formulation for solubilization. In the current study, a polymeric micellar (PM) formulation strategy was developed for a representative nerve-specific fluorophore from the distyrylbenzene family, BMB. The PM formulation strategy was able to solubilize BMB and demonstrated improved nerve-specific accumulation and fluorescence intensity when the same fluorophore dose was administered to mice utilizing the previous formulation strategy. The success of the PM formulation strategy will be important for moving toward clinical translation of these novel nerve-specific probes as it is nontoxic and biodegradable and has the potential to decrease the necessary dose for imaging while also improving the safety profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.