ArticleThe Journal of clinical investigation2015
Over-salting ruins the balance of the immune menu.
Article in The Journal of clinical investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of the Impact of Dietary Sodium on Autoimmunity and Inflammation Related to Multiple Sclerosis.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Effects of a Mediterranean Diet Compared with the Low-Fat Diet on Patients with Knee Osteoarthritis: A Randomized Feeding Trial.International journal of clinical practice · 2022Trial
- A nutritionally balanced menu for emergencies: beyond the COVID-19 pandemic.Frontiers in nutrition · 2026Article
- Article
- High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation.Military Medical Research · 2025Article
- Impact of high-salt diet in health and diseases and its role in pursuit of cancer immunotherapy by modulating gut microbiome.Journal of family medicine and primary care · 2024Review
- L-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation.Frontiers in immunology · 2024Article
- Microvascular Thrombosis as a Critical Factor in Severe COVID-19.International journal of molecular sciences · 2023Article
- Perspective: Darwinian Applications to Nutrition-The Value of Evolutionary Insights to Teachers and Students.Advances in nutrition (Bethesda, Md.) · 2022Article
- Sodium Toxicity in the Nutritional Epidemiology and Nutritional Immunology of COVID-19.Medicina (Kaunas, Lithuania) · 2021Article
- Mediterranean Diet as a Tool to Combat Inflammation and Chronic Diseases. An Overview.Biomedicines · 2020Review
- High-salt diet decreases mechanical thresholds in mice that is mediated by a CCR2-dependent mechanism.Journal of neuroinflammation · 2020Article
- Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation.The Journal of allergy and clinical immunology · 2018Article
- Nanomechanics of the endothelial glycocalyx contribute to NaScientific reports · 2017Article
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Authors and funding
2 authors.
Funding
Abstract
Regulatory components of the immune system are critical for preventing unintended activation of immune cells. Failure to prevent this unintended activation raises the risk of developing exaggerated inflammation and autoimmunity. In this issue of the JCI, Binger et al. and Hernandez et al. report that salt can play an important role in undermining regulatory mechanisms of the innate and adaptive immune systems. High salt levels interfere with alternative activation of macrophages (M2), which function in attenuating tissue inflammation and promoting wound healing. High salt also impairs Treg function by inducing IFNγ production in these cells. Together, these results provide evidence that environmental signals in the presence of high dietary salt enhance proinflammatory responses by interfering with both innate and adaptive regulatory mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.