Evidence map›Paper›PMID 26485218›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

Intra-Individual Consistency in Endocrine Profiles Across Successive Pregnancies.

Molly Fox, Curt A Sandman, Elysia Poggi Davis, Laura M Glynn

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Prenatal Risk for ASD: Fetal Cortisol Exposure Predicts Child Autism-Spectrum Disorder Symptoms.Clinical psychological science : a journal of the Association for Psychological Science · 2019
    Article
  3. Women's Pregnancy Life History and Alzheimer's Risk: Can Immunoregulation Explain the Link?American journal of Alzheimer's disease and other dementias · 2018
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Molly FoxDepartment of Pediatrics (M.F.) and Department of Psychiatry and Human Behavior (M.F., C.A.S., E.P.D., L.M.G.), University of California, Irvine, Irvine, California 92866; Department of Psychology (E.P.D.), University of Denver, Denver, Colorado 80208; and Department of Psychology (L.M.G.), Chapman University, Orange, California 92866.
Curt A SandmanDepartment of Pediatrics (M.F.) and Department of Psychiatry and Human Behavior (M.F., C.A.S., E.P.D., L.M.G.), University of California, Irvine, Irvine, California 92866; Department of Psychology (E.P.D.), University of Denver, Denver, Colorado 80208; and Department of Psychology (L.M.G.), Chapman University, Orange, California 92866.
Elysia Poggi DavisDepartment of Pediatrics (M.F.) and Department of Psychiatry and Human Behavior (M.F., C.A.S., E.P.D., L.M.G.), University of California, Irvine, Irvine, California 92866; Department of Psychology (E.P.D.), University of Denver, Denver, Colorado 80208; and Department of Psychology (L.M.G.), Chapman University, Orange, California 92866.
Laura M GlynnDepartment of Pediatrics (M.F.) and Department of Psychiatry and Human Behavior (M.F., C.A.S., E.P.D., L.M.G.), University of California, Irvine, Irvine, California 92866; Department of Psychology (E.P.D.), University of Denver, Denver, Colorado 80208; and Department of Psychology (L.M.G.), Chapman University, Orange, California 92866.
University of California, Irvine · USChapman University · USUniversity of Denver · US

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2013 to 2023
$25.4M
Maternal Stress and Fetal/Infant DevelopmentR01NS041298 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2002 to 2006
$2.8M
Pregnancy Influences Environmental SensitivityR01HD040967 · NICHD · UNIVERSITY OF CALIFORNIA IRVINE · PI GLYNN, LAURA M · 2001 to 2005
$1.7M
Effects of Acculturation on Gestational Biology in Mexican-American Pregnant WomenK01DK105110 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOX, MOLLY MAURER · 2015 to 2021
$782k
NICHD NIH HHS HD-40967NICHD NIH HHS R01 HD040967NIMH NIH HHS MH-96889NIMH NIH HHS P50 MH096889NINDS NIH HHS NS-41298NINDS NIH HHS R01 NS041298
6 · The paper itself

Abstract

contextIt is yet unknown how similar women's hormone levels are during successive pregnancies, and very little is known about the degree to which siblings experience similar prenatal environments. Given the importance of understanding how women's reproductive life histories exert cumulative effects on health via hormone exposure, and the importance of understanding how fetal programming via endocrine signaling affects sibling trait concordance, here, we address this important lacuna in the literature.

objectiveThis study aimed to investigate how consistent women's hormone profiles are across two successive pregnancies. DESIGN AND

main outcome measuresThis longitudinal, prospective study followed a cohort of 28 women across two pregnancies (PREG 1 and PREG 2). Women's circulating hormone levels were assessed from blood samples at 25, 31, and 37 weeks' gestation for adrenocorticotropic hormone (ACTH), placental corticotropin-releasing hormone (pCRH), cortisol, estradiol, and progesterone. ACTH and cortisol levels were assessed 3 months postpartum. Research questions include: Are hormone levels in PREG 2 significantly different from levels in PREG 1? What proportion of variance in PREG 2 hormone levels is attributable to variance in PREG 1 levels? Are hormone levels more stable between PREG 1 and PREG 2 compared with postpartum phases following these pregnancies? Is pCRH, which is completely placentally derived, less similar than other hormones across successive pregnancies? PARTICIPANTS AND

settingPregnant women attended study visits at a university psychobiology laboratory in Southern California. RESULTS AND

conclusionsComparisons of hormone concentrations across women's successive pregnancies via paired t test revealed substantial consistency from one pregnancy to another, with only significant differences between pregnancies for pCRH. Regressions revealed substantial predictability from one pregnancy to another, with between 17-56% of PREG 2 variances accounted for by PREG 1 values. Women exhibited lower degrees of consistency and predictability in hormone levels across postpartum phases compared with gestational concentrations. This is the first study to describe maternal and placental hormone levels across successive pregnancies.

Indexed as

Adrenocorticotropic HormoneAdultCohort StudiesCorticotropin-Releasing HormoneEndocrine SystemEthnicityFemaleFetal DevelopmentHormonesHumansLongitudinal StudiesPostpartum PeriodPregnancyProspective StudiesSocioeconomic FactorsAdrenocorticotropic HormoneCorticotropin-Releasing HormoneHormones

Identifiers

PMID26485218
PMCPMC4667165
OpenAlexW1848855012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.