ArticlePloS one2015
Using Agent-Based Modelling to Predict the Role of Wild Refugia in the Evolution of Resistance of Sea Lice to Chemotherapeutants.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Threshold-based disease treatment approach modulates economic, conservation and evolutionary trade-offs in sea louse-salmon aquaculture system.Theoretical ecology · 2025Article
- Applying genetic technologies to combat infectious diseases in aquaculture.Reviews in aquaculture · 2023Review
- A modeling study of the impact of treatment policies on the evolution of resistance in sea lice on salmon farms.PloS one · 2023Article
- Patterns of asexual reproduction of the soybean aphid,Frontiers in microbiology · 2023Article
- Parasite management in aquaculture exerts selection on salmon louse behaviour.Evolutionary applications · 2021Article
- The potential for cleaner fish-driven evolution in the salmon louseEcology and evolution · 2021Article
- Migratory hosts can maintain the high-dose/refuge effect in a structured host-parasite system: The case of sea lice and salmon.Evolutionary applications · 2020Article
- Sea lice exposure to non-lethal levels of emamectin benzoate after treatments: a potential risk factor for drug resistance.Scientific reports · 2020Article
- The Use of Kernel Density Estimation With a Bio-Physical Model Provides a Method to Quantify Connectivity Among Salmon Farms: Spatial Planning and Management With Epidemiological Relevance.Frontiers in veterinary science · 2018Article
- The Phe362Tyr mutation conveying resistance to organophosphates occurs in high frequencies in salmon lice collected from wild salmon and trout.Scientific reports · 2017Article
- Article
- Managing aquatic parasites for reduced drug resistance: lessons from the land.Journal of the Royal Society, Interface · 2016Article
- Lessons from sea louse and salmon epidemiology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Surveillance of the Sensitivity towards Antiparasitic Bath-Treatments in the Salmon Louse (Lepeophtheirus salmonis).PloS one · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major challenge for Atlantic salmon farming in the northern hemisphere is infestation by the sea louse parasite Lepeophtheirus salmonis. The most frequent method of controlling these sea louse infestations is through the use of chemical treatments. However, most major salmon farming areas have observed resistance to common chemotherapeutants. In terrestrial environments, many strategies employed to manage the evolution of resistance involve the use of refugia, where a portion of the population is left untreated to maintain susceptibility. While refugia have not been deliberately used in Atlantic salmon farming, wild salmon populations that migrate close to salmon farms may act as natural refugia. In this paper we describe an agent-based model that explores the influence of different sizes of wild salmon populations on resistance evolution in sea lice on a salmon farm. Using the model, we demonstrate that wild salmon populations can act as refugia that limit the evolution of resistance in the sea louse populations. Additionally, we demonstrate that an increase in the size of the population of wild salmon results in an increased effect in slowing the evolution of resistance. We explore the effect of a population fitness cost associated with resistance, finding that in some cases it substantially reduces the speed of evolution to chemical treatments.
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