Evidence map›Paper›PMID 26484951›Full record

Trial reportMedicine and science in sports and exercise2016

Ventilation Increases with Lower Extremity Venous Occlusion in Young Adults.

Manda L Keller-Ross, Andrielle L Sarkinen, Troy Cross, Bruce D Johnson, Thomas P Olson

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Medicine and science in sports and exercise, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manda L Keller-Ross1Program in Physical Therapy, University of Minnesota, Minneapolis, MN; and 2Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN.
Andrielle L Sarkinen
Troy Cross
Bruce D Johnson
Thomas P Olson

Funding

Musculoskeletal Research Training ProgramT32AR056950 · NIAMS · MAYO CLINIC ROCHESTER · PI Jennifer J Westendorf · 2009 to 2026
$7.0M
Mayo Clinic Center for Translational Science ActivitiesKL2TR000136 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$6.6M
Pulmonary Limitations in Chronic Heart FailureR01HL071478 · NHLBI · MAYO CLINIC ROCHESTER · PI JOHNSON, BRUCE D · 2002 to 2014
$3.7M
Peripheral Mechanisms of Cardiopulmonary Control during ExerciseR01HL126638 · NHLBI · MAYO CLINIC ROCHESTER · PI OLSON, THOMAS PATRICK · 2015 to 2019
$2.9M
NCATS NIH HHS KL2 TR000136NCATS NIH HHS KL2TR000136NHLBI NIH HHS HL71478NHLBI NIH HHS L30 HL090236NHLBI NIH HHS R01 HL071478NHLBI NIH HHS R01 HL126638NIAMS NIH HHS T32 AR056950NIAMS NIH HHS T32AR56950
6 · The paper itself

Abstract

introductionVenous distention via subsystolic occlusion of the lower limbs may augment ventilation via stimulation of group III/IV afferent neurons. PURPOSE: The purpose of this study was to examine the ventilatory response to graded lower extremity venous occlusion during exercise in healthy adults.

methodsNineteen adults (9 men, 25 ± 5 yr) completed two visits. Visit 1 included a maximal cycle ergometry exercise test. Visit 2 included a 30% peak workload cycle exercise with randomized inflations of bilateral thigh pressure tourniquets to 20, 40, 60, 80, and 100 mm Hg for 2 min each, separated by 2 min of deflation. Three minutes of cycling occurred before cuffing (control [CTL]). Expired minute ventilation (V˙E), whole body gas exchange, rating of perceived exertion, and dyspnea were measured during each session.

resultsV˙E increased significantly from the control condition (exercise only, CTL) to each occlusion pressure (P < 0.05) with the greatest increase at 100 mm Hg (CTL to 100 mm Hg: 31.5 ± 6.6 to 40.1 ± 10.7 L·min). Respiratory rate (RR) increased as well (CTL to 100 mm Hg: 24.8 ± 6.0 to 30.9 ± 11.5 breaths per minute, P < 0.05, condition effect) with no change in tidal volume (P > 0.05). Tidal volume to inspiratory time (VT/TI) increased significantly from the CTL condition to each occlusion pressure (CTL to 100 mm Hg: 1.5 ± 0.3 to 1.8 ± 0.4 L·min, P < 0.05, all pressures). Dyspnea and RPE increased with all occlusion pressures from CTL exercise (P < 0.05, all pressures).

conclusionsOur findings suggest that mild-to-moderate venous occlusion of the lower extremity evokes a tachypneic breathing pattern which, in turn, augments V˙E and perceived breathing effort during exercise.

Indexed as

Regional Blood FlowRespiratory RateTourniquetsAdultCarbon DioxideConstriction, PathologicExercise TestFemaleHumansLegMaleQuadriceps MuscleTidal VolumeYoung AdultCarbon Dioxide

Identifiers

PMID26484951
PMCPMC4760844

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.