ArticlePloS one2015
Analysis of the DNA-Binding Activities of the Arabidopsis R2R3-MYB Transcription Factor Family by One-Hybrid Experiments in Yeast.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 89 citations in OpenAlex.
- Natural variation in OsMYB305 downregulating cytokinin-mediated inhibition of leaf senescence contributes to regional adaptation in rice.The New phytologist · 2026Article
- A single-MYB transcription factor GmMYB331 regulates seed oil accumulation and seed size/weight in soybean.Journal of integrative plant biology · 2026Article
- The MabZIP5-MaMYB69 module cooperates with MaERF55 to modulate banana fruit ripening via cell wall degradation.Horticulture research · 2026Article
- The GAs-RhMYB70 feedback loop fine-tunes cell expansion and petal size by modulating cellulose content in rose.Horticulture research · 2025Article
- Genome-Wide Analysis of GmMYB S20 Transcription Factors Reveals Their Critical Role in Soybean Nodulation.Plants (Basel, Switzerland) · 2025Article
- ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia.Molecular plant · 2025Article
- Integrative analysis of metabolome and transcriptome reveals regulatory mechanisms of flavonoid biosynthesis in soybean under salt stress.Frontiers in plant science · 2024Article
- MYB24 orchestrates terpene and flavonol metabolism as light responses to anthocyanin depletion in variegated grape berries.The Plant cell · 2023Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2023Article
- Over-expression ofPeerJ · 2023Article
- Evidence for Light and Tissue Specific Regulation of Genes Involved in Fructan Metabolism inPlants (Basel, Switzerland) · 2022Article
- CROWN ROOTLESS1 binds DNA with a relaxed specificity and activates OsROP and OsbHLH044 genes involved in crown root formation in rice.The Plant journal : for cell and molecular biology · 2022Article
- Anthocyanins as Key Phytochemicals Acting for the Prevention of Metabolic Diseases: An Overview.Molecules (Basel, Switzerland) · 2022Review
- Integrated Transcriptomics and Widely Targeted Metabolomics Analyses Provide Insights Into Flavonoid Biosynthesis in the Rhizomes of Golden Buckwheat (Frontiers in plant science · 2022Article
- Article
- The Seed Development FactorsGenes · 2021Article
- MYB Transcription Factors and Its Regulation in Secondary Cell Wall Formation and Lignin Biosynthesis during Xylem Development.International journal of molecular sciences · 2021Review
- Identification of MBW Complex Components Implicated in the Biosynthesis of Flavonoids in Woodland Strawberry.Frontiers in plant science · 2021Article
- Characterization of the MYB Genes Reveals Insights Into Their Evolutionary Conservation, Structural Diversity, and Functional Roles inFrontiers in microbiology · 2021Article
- The MYB transcription factor CiMYB42 regulates limonoids biosynthesis in citrus.BMC plant biology · 2020Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The control of growth and development of all living organisms is a complex and dynamic process that requires the harmonious expression of numerous genes. Gene expression is mainly controlled by the activity of sequence-specific DNA binding proteins called transcription factors (TFs). Amongst the various classes of eukaryotic TFs, the MYB superfamily is one of the largest and most diverse, and it has considerably expanded in the plant kingdom. R2R3-MYBs have been extensively studied over the last 15 years. However, DNA-binding specificity has been characterized for only a small subset of these proteins. Therefore, one of the remaining challenges is the exhaustive characterization of the DNA-binding specificity of all R2R3-MYB proteins. In this study, we have developed a library of Arabidopsis thaliana R2R3-MYB open reading frames, whose DNA-binding activities were assayed in vivo (yeast one-hybrid experiments) with a pool of selected cis-regulatory elements. Altogether 1904 interactions were assayed leading to the discovery of specific patterns of interactions between the various R2R3-MYB subgroups and their DNA target sequences and to the identification of key features that govern these interactions. The present work provides a comprehensive in vivo analysis of R2R3-MYB binding activities that should help in predicting new DNA motifs and identifying new putative target genes for each member of this very large family of TFs. In a broader perspective, the generated data will help to better understand how TF interact with their target DNA sequences.
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