ArticleThe New phytologist2016
A novel nematode effector suppresses plant immunity by activating host reactive oxygen species-scavenging system.
Article in The New phytologist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 165 citations in OpenAlex.
- Redox Regulation of Plant-Root-Knot Nematode Interactions: From ROS-Mediated Immunity to Sustainable Resistance.Antioxidants (Basel, Switzerland) · 2026Review
- Status and advancement of root-knot nematode management strategies and the emerging CRISPR/Cas biotechnology application.Functional & integrative genomics · 2026Review
- Genome reannotation and gland-specific transcriptome analysis identify new effector candidates in Meloidogyne chitwoodi.PLoS pathogens · 2025Article
- Article
- Cellular plasticity and transcriptional reprogramming in plant-nematode interactions: insights into feeding site formation and plant defense.Crop health · 2025Review
- Mitochondrial Protein MjEF-Tu is Secreted into Host Plants by Nematodes Eliciting Immune Signaling and Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Alternaria alternata effector AaAlta1 targets CmWD40 and participates in regulating disease resistance in Chrysanthemum morifolium.PLoS pathogens · 2025Article
- Effectiveness of Plant-Induced Resistance Against Root-Knot Nematode Depends on the Policy of Using Inducer on the Host Plant.Current microbiology · 2025Article
- Root-Knot Nematode Early Infection Suppresses Immune Response and Elicits the Antioxidant System in Tomato.International journal of molecular sciences · 2024Article
- Cotton Bollworm (H. armigera) Effector PPI5 Targets FKBP17-2 to Inhibit ER Immunity and JA/SA Responses, Enhancing Insect Feeding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Root-knot nematodes exploit the catalase-like effector to manipulate plant reactive oxygen species levels by directly degrading HMolecular plant pathology · 2024Article
- Transcriptome Analysis ofPlants (Basel, Switzerland) · 2024Article
- Insights into the plant response to nematode invasion and modulation of host defense by plant parasitic nematode.Frontiers in microbiology · 2024Review
- AFrontiers in plant science · 2024Article
- Counter-attack of biocontrol agents: Environmentally benign Approaches against Root-knot nematodes (Heliyon · 2023Review
- Review
- Reactive Oxygen Species: A Crosslink between Plant and Human Eukaryotic Cell Systems.International journal of molecular sciences · 2023Review
- Biotechnological Tools to Elucidate the Mechanism of Plant and Nematode Interactions.Plants (Basel, Switzerland) · 2023Review
- In silico secretome analyses of the polyphagous root-knot nematode Meloidogyne javanica: a resource for studying M. javanica secreted proteins.BMC genomics · 2023Article
- Single Nematode Transcriptomic Analysis, Using Long-Read Technology, Reveals Two Novel Virulence Gene Candidates in the Soybean Cyst Nematode,International journal of molecular sciences · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence is emerging that plant-parasitic nematodes can secrete effectors to interfere with the host immune response, but it remains unknown how these effectors can conquer host immune responses. Here, we depict a novel effector, MjTTL5, that could suppress plant immune response. Immunolocalization and transcriptional analyses showed that MjTTL5 is expressed specifically within the subventral gland of Meloidogyne javanica and up-regulated in the early parasitic stage of the nematode. Transgenic Arabidopsis lines expressing MjTTL5 were significantly more susceptible to M. javanica infection than wild-type plants, and vice versa, in planta silencing of MjTTL5 substantially increased plant resistance to M. javanica. Yeast two-hybrid, coimmunoprecipitation and bimolecular fluorescent complementation assays showed that MjTTL5 interacts specifically with Arabidopsis ferredoxin : thioredoxin reductase catalytic subunit (AtFTRc), a key component of host antioxidant system. The expression of AtFTRc is induced by the infection of M. javanica. Interaction between AtFTRc and MjTTL could drastically increase host reactive oxygen species-scavenging activity, and result in suppression of plant basal defenses and attenuation of host resistance to the nematode infection. Our results demonstrate that the host ferredoxin : thioredoxin system can be exploited cunningly by M. javanica, revealing a novel mechanism utilized by plant-parasitic nematodes to subjugate plant innate immunity and thereby promoting parasitism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.