Evidence map›Paper›PMID 26484571›Full record

ArticleBiopreservation and biobanking2015

A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project.

Latarsha J Carithers, Kristin Ardlie, Mary Barcus, Philip A Branton, Angela Britton, Stephen A Buia, Carolyn C Compton, David S DeLuca, Joanne Peter-Demchok, Ellen T Gelfand and 18 more

Open access · hybridAbstract read
In one paragraph

Article in Biopreservation and biobanking, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 539 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
539citing papers in PubMed, 4 pooled it
33.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

539 citing papers in PubMed, 4 syntheses or guidelines pooled it, 915 citations in OpenAlex.

  1. Pooled it
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  15. Gut-reproduction axis: genome-wide pleiotropic and prospective evidence linking inflammatory bowel disease with gynecological disorders.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  20. Integrative Genomic Analyses IdentifybioRxiv : the preprint server for biology · 2026
    Article

479 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 3 institutions in 1 country.

Latarsha J Carithers1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
Kristin Ardlie2 The Broad Institute of MIT and Harvard , Cambridge, Massachusetts.
Mary Barcus3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Philip A Branton1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
Angela Britton3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Stephen A Buia3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Carolyn C Compton1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
David S DeLuca2 The Broad Institute of MIT and Harvard , Cambridge, Massachusetts.
Joanne Peter-Demchok1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
Ellen T Gelfand2 The Broad Institute of MIT and Harvard , Cambridge, Massachusetts.
Ping Guan1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
Greg E Korzeniewski3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Nicole C Lockhart1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
Chana A Rabiner1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
Abhi K Rao1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
Karna L Robinson3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Nancy V Roche3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Sherilyn J Sawyer1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
Ayellet V Segrè2 The Broad Institute of MIT and Harvard , Cambridge, Massachusetts.
Charles E Shive3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Anna M Smith3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Leslie H Sobin3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Anita H Undale3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Kimberly M Valentino3 Biospecimen Research Group, Clinical Research Directorate, Leidos Biomedical Research, Inc. , Frederick, Maryland.
Jim Vaught1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
Taylor R Young2 The Broad Institute of MIT and Harvard , Cambridge, Massachusetts.
Helen M Moore1 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, National Cancer Institute (NCI), National Institutes of Health (NIH) , Bethesda, Maryland.
GTEx Consortium
Leidos (United States) · USNational Institutes of Health · USBroad Institute · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
LIMBIC &MEDULLARY MECH. IN COCAINE-RELATED SUDDEN DEATHR01DA006227 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MASH, DEBORAH C. · 1990 to 2012
$3.7M
Epigenomic variation atlas across human tissues and individuals in GTExU01HG007610 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS · 2014 to 2016
$3.0M
NCI NIH HHS P30 CA016056NHGRI NIH HHS U01 HG007610NIDA NIH HHS R01 DA006227-17NIDDK NIH HHS P30 DK020595OHS HRSA HHS 10ST1035OHS HRSA HHS 12ST1039PHS HHS 10X172PHS HHS 10XS170PHS HHS 10XS171PHS HHS HHSN261200800001EPHS HHS HHSN268201000029C
6 · The paper itself

Abstract

The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community.

Indexed as

Biomedical ResearchTissue and Organ ProcurementTissue BanksHumans

Identifiers

PMID26484571
PMCPMC4675181
OpenAlexW2342127666

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.