ArticleRadiation oncology journal2015
Radioprotective effect of mefenamic acid against radiation-induced genotoxicity in human lymphocytes.
Article in Radiation oncology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Crosstalk between Oxidative Stress and Inflammation Induced by Ionizing Radiation in Healthy and Cancerous Cells.Current medicinal chemistry · 2024Review
- Niosomal formulation of mefenamic acid for enhanced cancer targeting; preparation, characterization and biodistribution study using radiolabeling technique.Journal of cancer research and clinical oncology · 2023Article
- Review
- Mefenamic acid as a promising therapeutic medicine against colon cancer in tumor-bearing mice.Medical oncology (Northwood, London, England) · 2022Article
- Fluoxetine as an antidepressant medicine improves the effects of ionizing radiation for the treatment of glioma.Journal of bioenergetics and biomembranes · 2020Article
- Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast.Archives of toxicology · 2020Review
- Radioprotective effect of diethylcarbamazine on radiation-induced acute lung injury and oxidative stress in mice.Journal of bioenergetics and biomembranes · 2020Article
- Article
- Radioprotective effect of olanzapine as an anti-psychotic drug against genotoxicity and apoptosis induced by ionizing radiation on human lymphocytes.Molecular biology reports · 2019Article
- The synergistic effect of mefenamic acid with ionizing radiation in colon cancer.Journal of bioenergetics and biomembranes · 2019Article
- Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation.Drug design, development and therapy · 2019Article
- Radioprotective Effect of Gliclazide as an Anti-Hyperglycemic Agent Against Genotoxicity Induced by Ionizing Radiation on Human Lymphocytes.Cardiovascular & hematological agents in medicinal chemistry · 2019Article
- C1QBP is upregulated in colon cancer and binds to apolipoprotein A-I.Experimental and therapeutic medicine · 2017Article
- Celecoxib mitigates genotoxicity induced by ionizing radiation in human blood lymphocytes.Research in pharmaceutical sciences · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMefenamic acid (MEF) as a non-steroidal anti-inflammatory drug is used as a medication for relieving of pain and inflammation. Radiation-induced inflammation process is involved in DNA damage and cell death. In this study, the radioprotective effect of MEF was investigated against genotoxicity induced by ionizing radiation in human blood lymphocytes. MATERIALS AND
methodsPeripheral blood samples were collected from human volunteers and incubated with MEF at different concentrations (5, 10, 50, or 100 µM) for two hours. The whole blood was exposed to ionizing radiation at a dose 1.5 Gy. Lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis blocked binucleated lymphocyte.
resultsA significant decreasing in the frequency of micronuclei was observed in human lymphocytes irradiated with MEF as compared to irradiated lymphocytes without MEF. The maximum decreasing in frequency of micronuclei was observed at 100 µM of MEF (38% decrease), providing maximal protection against ionizing radiation.
conclusionThe radioprotective effect of MEF is probably related to anti-inflammatory property of MEF on human lymphocytes.
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