Analytical sequence to study G-CSF effect on the transcriptome of isolated spinal motoneurons from SOD1 G93A mice, an animal model for amyotrophic lateral sclerosis.

Alexandre Henriques, Stefan Kastner, Oliver Wafzig, Jose-Luis Gonzalez De Aguilar, Armin Schneider

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In one paragraph

Article in Genomics data, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Alexandre HenriquesINSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France ; UMRS1118, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, France.

Stefan KastnerSygnis Bioscience GmbH & Co KG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany.

Oliver WafzigSygnis Bioscience GmbH & Co KG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany.

Jose-Luis Gonzalez De AguilarINSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France ; UMRS1118, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, France.

Armin SchneiderSygnis Bioscience GmbH & Co KG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany.

Expedeon (Germany) · DEInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Granulocyte-colony stimulating factor (G-CSF) has been recently identified as a neurotrophic factor able to preserve motor functions, rescue motor units and extent survival in an animal model of amyotrophic lateral sclerosis, the SOD1 G93A mice. To gain insight into the mode of action of G-CSF, we have recently performed gene expression profiling on isolated lumbar motoneurons from SOD1G93A mice, and shown that G-CSF re-adjusted gene expression in motoneurons of symptomatic SOD1G93A mice and modulates genes related to neuromuscular function (Henriques et al., 2015). Here, we provide quality controls for the microarray experiment (GO accession number GSE60856) and describe the experimental strategy.

Indexed as

ALSG-CSFGene expressionLaser microdissectionMotor neuron

Identifiers

PMID26484174

DOI10.1016/j.gdata.2015.02.003

PMCPMC4535899

OpenAlexW1964548945

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.