Evidence map›Paper›PMID 26483967›Full record

ArticleActa naturae

5-Arylaminouracil Derivatives as Potential Dual-Action Agents.

E S Matyugina, M S Novikov, D A Babkov, V T Valuev-Elliston, C Vanpouille, S Zicari, A Corona, E Tramontano, L B Margolis, A L Khandazhinskaya and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 72% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

E S MatyuginaEngelhardt Institute of Molecular Biology, Vavilova Str., 32, Moscow, 119991, Russia.
M S NovikovDepartment of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd, 400131, Russia.
D A BabkovDepartment of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd, 400131, Russia.
V T Valuev-EllistonEngelhardt Institute of Molecular Biology, Vavilova Str., 32, Moscow, 119991, Russia.
C VanpouilleEunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
S ZicariEunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
A CoronaDepartment of Life and Environmental Sciences, University of Cagliari, Monserrato, 09042, Italy.
E TramontanoDepartment of Life and Environmental Sciences, University of Cagliari, Monserrato, 09042, Italy.
L B MargolisEunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
A L KhandazhinskayaEngelhardt Institute of Molecular Biology, Vavilova Str., 32, Moscow, 119991, Russia.
S N KochetkovEngelhardt Institute of Molecular Biology, Vavilova Str., 32, Moscow, 119991, Russia.
Engelhardt Institute of Molecular Biology · RUEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Cagliari · ITVolgograd State Medical University · RU

Funding

Cell Interactions in Three Dimensional Tissue CultureZIAHD001416 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MARGOLIS, LEONID B. · 2009 to 2017
$15.7M
6 · The paper itself

Abstract

Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5-40 μg/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without causing toxicity in vitro (MT-4 cells) and ex vivo (human tonsillar tissue).

Indexed as

5’-norcarbocyclic nucleoside analogs5-(phenylamino)uracil derivativesdual actionHIV and Mycobacterium tuberculosis co-infection

Identifiers

PMID26483967
PMCPMC4610172
OpenAlexW2959336226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.