Evidence map›Paper›PMID 26483951›Full record

ArticleSleep science (Sao Paulo, Brazil)

Recurrent hypersomnia: Report of medication-responsive cases.

Bruna V Perin, Iorrana Rodrigues, Franciele T B Giasson, Matheus Balen, Naiana Posenato, Cassiano M Forcelini

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep science (Sao Paulo, Brazil). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Kleine-Levin syndrome: clues to aetiology.Sleep & breathing = Schlaf & Atmung · 2018
    Review
  2. Kleine-Levin Syndrome.Current treatment options in neurology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bruna V PerinFaculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil.
Iorrana RodriguesFaculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil.
Franciele T B GiassonFaculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil.
Matheus BalenFaculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil.
Naiana PosenatoInstituto de Neurologia e Neurocirurgia (INN), R. Uruguai 1555, 5º andar, Centro, CEP, 99010-112 Passo Fundo, RS, Brazil.
Cassiano M ForceliniFaculdade de Medicina, Universidade de Passo Fundo (UPF), R. Teixeira Soares 817, Centro, CEP, 99010-080 Passo Fundo, RS, Brazil ; Instituto de Neurologia e Neurocirurgia (INN), R. Uruguai 1555, 5º andar, Centro, CEP, 99010-112 Passo Fundo, RS, Brazil.
Universidade de Passo Fundo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRecurrent hypersomnia (RH) is a rare disorder without established treatment.

methodsWe report 2 RH medication-responsive cases with typical characteristics of Kleine-Levin syndrome (KLS). CASE-REPORTS: A 10 y.o. girl and a 14 y.o. boy presented with sudden sleepiness for 3-9 days (every 2-3 weeks). Physical examination, brain images and blood tests were normal. Polysomnographic findings were heterogenous, including disrupted sleep architecture. MSLTs revealed 2-3 SOREMPs and short sleep latency. Carbamazepine rendered girl׳s sleep normalization, while risperidone normalized boy׳s sleep cycles.

conclusionsFacing the absence of clinical trials in RH, reports of responsive cases are the available therapeutic evidence.

Indexed as

CarbamazepineKleine–Levin syndromeRecurrent hypersomniaRisperidoneTreatment

Identifiers

PMID26483951
PMCPMC4608889
OpenAlexW758282109

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.