ArticleFrontiers in genetics2015
Evolution of epithelial morphogenesis: phenotypic integration across multiple levels of biological organization.
Article in Frontiers in genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Genomic resources for the scuttle fly Megaselia abdita: a model organism for comparative developmental studies in flies.Development (Cambridge, England) · 2025Article
- Article
- A two-level staging system for the embryonic morphogenesis of the Mediterranean fruit fly (medfly) Ceratitis capitata.PloS one · 2024Article
- Extraembryonic tissue in chelicerates: a review and outlook.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Review of extra-embryonic tissues in the closest arthropod relatives, onychophorans and tardigrades.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Co-option of stress mechanisms in the origin of evolutionary novelties.Evolution; international journal of organic evolution · 2022Article
- Unexpected mutual regulation underlies paralogue functional diversification and promotes epithelial tissue maturation in Tribolium.Communications biology · 2020Article
- Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle flyeLife · 2018Article
- Light Sheet-based Fluorescence Microscopy of Living or Fixed and Stained Tribolium castaneum Embryos.Journal of visualized experiments : JoVE · 2017Article
- What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal cancers?Journal of cell communication and signaling · 2017Article
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- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenesis involves the dynamic reorganization of cell and tissue shapes to create the three-dimensional body. Intriguingly, different species have evolved different morphogenetic processes to achieve the same general outcomes during embryonic development. How are meaningful comparisons between species made, and where do the differences lie? In this Perspective, we argue that examining the evolution of embryonic morphogenesis requires the simultaneous consideration of different levels of biological organization: (1) genes, (2) cells, (3) tissues, and (4) the entire egg, or other gestational context. To illustrate the importance of integrating these levels, we use the extraembryonic epithelia of insects-a lineage-specific innovation and evolutionary hotspot-as an exemplary case study. We discuss how recent functional data, primarily from RNAi experiments targeting the Hox3/Zen and U-shaped group transcription factors, provide insights into developmental processes at all four levels. Comparisons of these data from several species both challenge and inform our understanding of homology, in assessing how the process of epithelial morphogenesis has itself evolved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.