ArticleFrontiers in plant science2015
The transporter GAT1 plays an important role in GABA-mediated carbon-nitrogen interactions in Arabidopsis.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Patch-Clamp- andPlant, cell & environment · 2025Article
- GABA transport: beyond stress? A closer look at AtGAT2.Journal of experimental botany · 2024Article
- Advances in Plant GABA Research: Biological Functions, Synthesis Mechanisms and Regulatory Pathways.Plants (Basel, Switzerland) · 2024Review
- Gamma-aminobutyric acid interactions with phytohormones and its role in modulating abiotic and biotic stress in plants.Stress biology · 2024Review
- Types of Membrane Transporters and the Mechanisms of Interaction between Them and Reactive Oxygen Species in Plants.Antioxidants (Basel, Switzerland) · 2024Review
- Exogenous γ-aminobutyric acid improves the photosynthesis efficiency, soluble sugar contents, and mineral nutrients in pomegranate plants exposed to drought, salinity, and drought-salinity stresses.BMC plant biology · 2023Article
- Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?eLife · 2023Review
- GABA Metabolism, Transport and Their Roles and Mechanisms in the Regulation of Abiotic Stress (Hypoxia, Salt, Drought) Resistance in Plants.Metabolites · 2023Review
- Investigation of bacterial diversity using 16S rRNA sequencing and prediction of its functionalities in Moroccan phosphate mine ecosystem.Scientific reports · 2022Article
- Comparative Transcriptome Analysis of Onion in Response to Infection byFrontiers in plant science · 2022Article
- Potential metabolic mechanisms for inhibited chloroplast nitrogen assimilation under high CO2.Plant physiology · 2021Article
- γ-Aminobutyrate (GABA) Regulated Plant Defense: Mechanisms and Opportunities.Plants (Basel, Switzerland) · 2021Review
- Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata.PloS one · 2020Article
- The interplay between miR156/SPL13 and DFR/WD40-1 regulate drought tolerance in alfalfa.BMC plant biology · 2019Article
- A Novel Gene Coding γ-Aminobutyric Acid Transporter May Improve the Tolerance ofFrontiers in plant science · 2019Article
- Article
- The PhotorespiratoryFrontiers in plant science · 2018Article
- Subcellular compartmentation of 4-aminobutyrate (GABA) metabolism in arabidopsis: An update.Plant signaling & behavior · 2017Article
- γ-Aminobutyric acid (GABA) signalling in plants.Cellular and molecular life sciences : CMLS · 2017Review
- Identification of twoPeerJ · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate derived γ-aminobutyric acid (GABA) is synthetized in the cytosol prior to delivery to the mitochondria where it is catabolized via the TCA cycle. GABA accumulates under various environmental conditions, but an increasing number of studies show its involvement at the crossroad between C and N metabolism. To assess the role of GABA in modulating cellular metabolism, we exposed seedlings of A. thaliana GABA transporter gat1 mutant to full nutrition medium and media deficient in C and N combined with feeding of different concentrations (0.5 and 1 mM) of exogenous GABA. GC-MS based metabolite profiling showed an expected effect of medium composition on the seedlings metabolism of mutant and wild type alike. That being said, a significant interaction between GAT1 deficiency and medium composition was determined with respect to magnitude of change in relative amino acid levels. The effect of exogenous GABA treatment on metabolism was contingent on both the medium and the genotype, leading for instance to a drop in asparagine under full nutrition and low C conditions and glucose under all tested media, but not to changes in GABA content. We additionally assessed the effect of GAT1 deficiency on the expression of glutamate metabolism related genes and genes involved in abiotic stress responses. These results suggest a role for GAT1 in GABA-mediated metabolic alterations in the context of the C-N equilibrium of plant cells.
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