Evidence map›Paper›PMID 26483478›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2015

Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution.

Xiao-Guang Chen, Xuanting Jiang, Jinbao Gu, Meng Xu, Yang Wu, Yuhua Deng, Chi Zhang, Mariangela Bonizzoni, Wannes Dermauw, John Vontas and 22 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 161 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 1 pooled it
38.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 1 synthesis or guideline pooled it, 311 citations in OpenAlex.

  1. Genomic investigations of successful invasions: the picture emerging from recent studies.Biological reviews of the Cambridge Philosophical Society · 2025
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  7. Distinct Swimming Behaviours in Pupae ofEcology and evolution · 2026
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  10. Putative Novel Viruses in the FamiliesAdvances in virology · 2026
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  14. TheProceedings of the National Academy of Sciences of the United States of America · 2025
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  15. Article
  16. The molecular toll pathway repertoire in anopheline mosquitoes.Developmental and comparative immunology · 2025
    Article
  17. Article
  18. The making of a dangerous vector: factors shaping the vector competence ofFrontiers in cellular and infection microbiology · 2025
    Review
  19. Article
  20. The Molecular Toll Pathway Repertoire in Anopheline Mosquitoes.bioRxiv : the preprint server for biology · 2024
    Article

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 12 institutions in 7 countries.

Xiao-Guang ChenDepartment of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China; 18664867266@qq.com fangxd@genomics.cn aajames@uci.edu.
Xuanting JiangBeijing Genomics Institute-Shenzhen, Shenzhen 518083, China;
Jinbao GuDepartment of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China;
Meng XuBeijing Genomics Institute-Shenzhen, Shenzhen 518083, China;
Yang WuDepartment of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China;
Yuhua DengDepartment of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China;
Chi ZhangBeijing Genomics Institute-Shenzhen, Shenzhen 518083, China;
Mariangela BonizzoniProgram in Public Health, University of California, Irvine, CA 92697; Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy;
Wannes DermauwLaboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, B-9000 Ghent, Belgium;ORCID http://orcid.org/0000-0003-4612-8969
John VontasInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 73100 Heraklion, Greece; Faculty of Crop Science, Pesticide Science Lab, Agricultural University of Athens, 11855 Athens, Greece;
Peter ArmbrusterDepartment of Biology, Georgetown University, Washington, DC 20057;
Xin HuangDepartment of Biology, Georgetown University, Washington, DC 20057;
Yulan YangBeijing Genomics Institute-Shenzhen, Shenzhen 518083, China;
Hao ZhangDepartment of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China;
Weiming HeBeijing Genomics Institute-Shenzhen, Shenzhen 518083, China;
Hongjuan PengDepartment of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China;
Yongfeng LiuBeijing Genomics Institute-Shenzhen, Shenzhen 518083, China;
Kun WuDepartment of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China;
Jiahua ChenBeijing Genomics Institute-Shenzhen, Shenzhen 518083, China;
Manolis LirakisDepartment of Biology, University of Crete, Heraklion, GR-74100, Crete, Greece;
Pantelis TopalisInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 73100 Heraklion, Greece;
Thomas Van LeeuwenDepartment of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy; Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, 1090 GE Amsterdam, The Netherlands;
Andrew Brantley HallInterdisciplinary PhD Program in Genetics, Bioinformatics, and Computational Biology, Virginia Tech University, Blacksburg, VA 24061; Department of Biochemistry, Fralin Life Science Institute, Virginia Tech University, Blacksburg, VA 24061;
Xiaofang JiangInterdisciplinary PhD Program in Genetics, Bioinformatics, and Computational Biology, Virginia Tech University, Blacksburg, VA 24061; Department of Biochemistry, Fralin Life Science Institute, Virginia Tech University, Blacksburg, VA 24061;
Chevon ThorpeCellular and Molecular Physiology, Edward Via College of Osteopathic Medicine, Blacksburg, VA 24060;
Rachel Lockridge MuellerDepartment of Biology, Colorado State University, Fort Collins, CO 80523;
Cheng SunDepartment of Biology, Colorado State University, Fort Collins, CO 80523;
Robert Michael WaterhouseDepartment of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland; Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139; The Broad Institute of MIT and Harvard, Cambridge, MA 02142;
Guiyun YanDepartment of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China; Program in Public Health, University of California, Irvine, CA 92697;
Zhijian Jake TuInterdisciplinary PhD Program in Genetics, Bioinformatics, and Computational Biology, Virginia Tech University, Blacksburg, VA 24061; Department of Biochemistry, Fralin Life Science Institute, Virginia Tech University, Blacksburg, VA 24061;
Xiaodong FangBeijing Genomics Institute-Shenzhen, Shenzhen 518083, China; 18664867266@qq.com fangxd@genomics.cn aajames@uci.edu.
Anthony A JamesDepartments of Microbiology & Molecular Genetics and Molecular Biology & Biochemistry, University of California, Irvine, CA 92697 18664867266@qq.com fangxd@genomics.cn aajames@uci.edu.
BGI Group (China) · CNSouthern Medical University · CNUniversity of California, Irvine · USColorado State University · USGeorgetown University · USGhent University · BEVirginia Tech · USAgricultural University of Athens · GRBroad Institute · USEdward Via College of Osteopathic Medicine · USFoundation for Research and Technology Hellas · GRUniversity of Crete · GR

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Expression of Exogenous Genes in Vector MosquitoesR37AI029746 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JAMES, ANTHONY A. · 2007 to 2016
$3.6M
Vector-borne Disease Research Training Program in ChinaD43TW009527 · FIC · UNIVERSITY OF CALIFORNIA-IRVINE · PI YAN, GUIYUN · 2013 to 2016
$600k
Impacts of Urbanization on Vector Biology and Transmission of Dengue in ChinaR01AI083202 · NIAID · SOUTHERN MEDICAL UNIVERSITY · PI CHEN, XIAOGUANG · 2010 to 2013
$413k
FIC NIH HHS D43 TW009527FIC NIH HHS D43TW009527NCATS NIH HHS UL1 TR001414NIAID NIH HHS AI083202NIAID NIH HHS R01 AI083202NIAID NIH HHS R37 AI029746
6 · The paper itself

Abstract

The Asian tiger mosquito, Aedes albopictus, is a highly successful invasive species that transmits a number of human viral diseases, including dengue and Chikungunya fevers. This species has a large genome with significant population-based size variation. The complete genome sequence was determined for the Foshan strain, an established laboratory colony derived from wild mosquitoes from southeastern China, a region within the historical range of the origin of the species. The genome comprises 1,967 Mb, the largest mosquito genome sequenced to date, and its size results principally from an abundance of repetitive DNA classes. In addition, expansions of the numbers of members in gene families involved in insecticide-resistance mechanisms, diapause, sex determination, immunity, and olfaction also contribute to the larger size. Portions of integrated flavivirus-like genomes support a shared evolutionary history of association of these viruses with their vector. The large genome repertory may contribute to the adaptability and success of Ae. albopictus as an invasive species.

Indexed as

Evolution, MolecularGenome, InsectAedesAnimalsPhylogenydiapauseflavivirusinsecticide resistancemosquito genometransposons

Identifiers

PMID26483478
PMCPMC4640774
OpenAlexW1908905777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.