Evidence map›Paper›PMID 26483472›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2015

Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns.

James Y Zou, Danny S Park, Esteban G Burchard, Dara G Torgerson, Maria Pino-Yanes, Yun S Song, Sriram Sankararaman, Eran Halperin, Noah Zaitlen

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Article
  5. Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
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  9. Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  10. Review
  11. Article
  12. Human genetic admixture.PLoS genetics · 2021
    Review
  13. On the heterozygosity of an admixed population.Journal of mathematical biology · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

James Y ZouMicrosoft Research, Cambridge, MA 02142; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142; jazo@microsoft.com.
Danny S ParkDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143;
Esteban G BurchardDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143; Department of Medicine, University of California, San Francisco, CA 94143;
Dara G TorgersonDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143; Department of Medicine, University of California, San Francisco, CA 94143;
Maria Pino-YanesDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143; Department of Medicine, University of California, San Francisco, CA 94143;
Yun S SongComputer Science Division, University of California, Berkeley, CA 94720; Department of Statistics, University of California, Berkeley, CA 94720; Department of Integrative Biology, University of California, Berkeley, CA 94720;
Sriram SankararamanDepartment of Genetics, Harvard Medical School, Boston, MA 02115;
Eran HalperinBlavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69102, Israel.
Noah ZaitlenDepartment of Medicine, University of California, San Francisco, CA 94143;
University of California, San Francisco · USHarvard University · USMicrosoft (United States) · USTel Aviv University · ILUniversity of California, Berkeley · US

Funding

Postdoctoral training in tobacco controlR25CA113710 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLANTZ, STANTON ARNOLD · 2006 to 2015
$5.4M
Whole Genome Analyses for Asthma in Latino PopulationsR01HL088133 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$3.8M
Mathematical Models and Statistical Methods for Large-Scale Population GenomicsR01GM094402 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SONG, YUN S · 2010 to 2018
$2.2M
Richer Models of Asthma Risk: Bridging the Environment-Genetics DivideK25HL121295 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAITLEN, NOAH A · 2014 to 2018
$784k
Statistical methods to infer structure and impact of ancient admixtureK99GM111744 · NIGMS · HARVARD MEDICAL SCHOOL · PI SANKARARAMAN, SRIRAM · 2014 to 2015
$128k
NCI NIH HHS R25 CA113710NCI NIH HHS R25CA113710NHLBI NIH HHS K25 HL121295NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01HL088133NIGMS NIH HHS K99 GM111744NIGMS NIH HHS R01 GM094402NIGMS NIH HHS R01-GM094402PHS HHS U19A1077439
6 · The paper itself

Abstract

Nonrandom mating in human populations has important implications for genetics and medicine as well as for economics and sociology. In this study, we performed an integrative analysis of a large cohort of Mexican and Puerto Rican couples using detailed socioeconomic attributes and genotypes. We found that in ethnically homogeneous Latino communities, partners are significantly more similar in their genomic ancestries than expected by chance. Consistent with this, we also found that partners are more closely related--equivalent to between third and fourth cousins in Mexicans and Puerto Ricans--than matched random male-female pairs. Our analysis showed that this genomic ancestry similarity cannot be explained by the standard socioeconomic measurables alone. Strikingly, the assortment of genomic ancestry in couples was consistently stronger than even the assortment of education. We found enriched correlation of partners' genotypes at genes known to be involved in facial development. We replicated our results across multiple geographic locations. We discuss the implications of assortment and assortment-specific loci on disease dynamics and disease mapping methods in Latinos.

Indexed as

Genetics, MedicalHispanic or LatinoInterpersonal RelationsSocioeconomic FactorsCohort StudiesFemaleHeterozygoteHumansMaleMexicoPuerto Ricoassortative matinggenomic ancestryhomogamy

Identifiers

PMID26483472
PMCPMC4640764
OpenAlexW2136519995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.