ArticleProceedings of the National Academy of Sciences of the United States of America2015
Synaptic circuits and their variations within different columns in the visual system of Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.
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Who cites it
115 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Imprecision in Vision: Lessons From Neural Circuits in the Fly.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
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- Sparse Annotation is Sufficient for Bootstrapping Dense Segmentation.Research square · 2024Article
- Sparse Annotation is Sufficient for Bootstrapping Dense Segmentation.bioRxiv : the preprint server for biology · 2024Article
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- Neuronal identity control at the resolution of a single transcription factor isoform.bioRxiv : the preprint server for biology · 2024Article
- Hue selectivity from recurrent circuitry in Drosophila.Nature neuroscience · 2024Article
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- Spatial patterning controls neuron numbers in the Drosophila visual system.Developmental cell · 2024Article
- A Closer Look at Histamine inInternational journal of molecular sciences · 2024Review
- Neuronal "parts list" and wiring diagram for a visual system.bioRxiv : the preprint server for biology · 2024Article
- Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome.Neuron · 2024Article
55 more citing papers are in PubMed but not listed here.
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Authors and funding
29 authors.
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Abstract
We reconstructed the synaptic circuits of seven columns in the second neuropil or medulla behind the fly's compound eye. These neurons embody some of the most stereotyped circuits in one of the most miniaturized of animal brains. The reconstructions allow us, for the first time to our knowledge, to study variations between circuits in the medulla's neighboring columns. This variation in the number of synapses and the types of their synaptic partners has previously been little addressed because methods that visualize multiple circuits have not resolved detailed connections, and existing connectomic studies, which can see such connections, have not so far examined multiple reconstructions of the same circuit. Here, we address the omission by comparing the circuits common to all seven columns to assess variation in their connection strengths and the resultant rates of several different and distinct types of connection error. Error rates reveal that, overall, <1% of contacts are not part of a consensus circuit, and we classify those contacts that supplement (E+) or are missing from it (E-). Autapses, in which the same cell is both presynaptic and postsynaptic at the same synapse, are occasionally seen; two cells in particular, Dm9 and Mi1, form ≥ 20-fold more autapses than do other neurons. These results delimit the accuracy of developmental events that establish and normally maintain synaptic circuits with such precision, and thereby address the operation of such circuits. They also establish a precedent for error rates that will be required in the new science of connectomics.
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