ArticleOncotarget2015
Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Physical Forces in Glioblastoma Migration: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Identifying senescent cells as prognostic biomarkers and therapeutic targets of nasopharyngeal carcinoma by integrated analysis of single-cell and bulk-RNA sequencing data.Translational cancer research · 2025Article
- The states of senescent cells.Biochemical Society transactions · 2025Review
- Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migration.Scientific reports · 2024Article
- Review
- Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension.PNAS nexus · 2023Article
- Jamming Transitions in Astrocytes and Glioblastoma Are Induced by Cell Density and Tension.Cells · 2022Article
- Multi-omics analysis of an in vitro photoaging model and protective effect of umbilical cord mesenchymal stem cell-conditioned medium.Stem cell research & therapy · 2022Article
- Modeling of the Senescence-Associated Phenotype in Human Skin Fibroblasts.International journal of molecular sciences · 2022Article
- Cellular senescence in cancer: from mechanisms to detection.Molecular oncology · 2021Review
- Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Senescent mesenchymal stem cells remodel extracellular matrix driving breast cancer cells to a more-invasive phenotype.Journal of cell science · 2020Article
- YAP and TAZ regulate cell volume.The Journal of cell biology · 2019Article
- Unmasking senescence: context-dependent effects of SASP in cancer.Nature reviews. Cancer · 2019Review
- The Cytoskeleton-A Complex Interacting Meshwork.Cells · 2019Review
- Senescent cell clearance by the immune system: Emerging therapeutic opportunities.Seminars in immunology · 2018Review
- Biophysical and biomolecular determination of cellular age in humans.Nature biomedical engineering · 2017Article
- The Mechanics of Single Cell and Collective Migration of Tumor Cells.Journal of biomechanical engineering · 2017Review
- PI3Kα isoform-dependent activation of RhoA regulates Wnt5a-induced osteosarcoma cell migration.Cancer cell international · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Cells induced into senescence exhibit a marked increase in the secretion of pro-inflammatory cytokines termed senescence-associated secretory phenotype (SASP). Here we report that SASP from senescent stromal fibroblasts promote spontaneous morphological changes accompanied by an aggressive migratory behavior in originally non-motile human breast cancer cells. This phenotypic switch is coordinated, in space and time, by a dramatic reorganization of the actin and microtubule filament networks, a discrete polarization of EB1 comets, and an unconventional front-to-back inversion of nucleus-MTOC polarity. SASP-induced morphological/migratory changes are critically dependent on microtubule integrity and dynamics, and are coordinated by the inhibition of RhoA and cell contractility. RhoA/ROCK inhibition reduces focal adhesions and traction forces, while promoting a novel gliding mode of migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.