Evidence map›Paper›PMID 26483316›Full record

ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2015

Gene expression and TB pathogenesis in rhesus macaques: TR4, CD40, CD40L, FAS (CD95), and TNF are host genetic markers in peripheral blood mononuclear cells that are associated with severity of TB lesions.

Morteza Roodgar, Cody T Ross, Ross Tarara, Linda Lowenstine, Satya Dandekar, David Glenn Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Interferon Epsilon: Properties and Functions.Current molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Morteza RoodgarGraduate Group of Comparative Pathology, University of California, Davis, United States. Electronic address: mroodgar@ucdavis.edu.
Cody T RossDepartment of Anthropology, University of California, Davis, United States.
Ross TararaCalifornia National Primate Research Center (CNPRC), University of California Davis, Davis, CA 95616, United States.
Linda LowenstinePathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, United States.
Satya DandekarMedical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA 95616, United States.
David Glenn SmithGraduate Group of Comparative Pathology, University of California, Davis, United States; Department of Anthropology, University of California, Davis, United States; California National Primate Research Center (CNPRC), University of California Davis, Davis, CA 95616, United States.
University of California, Davis · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
Development, Management and Use of a SNP Map for Rhesus MacaqueR24RR025871 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SMITH, DAVID GLENN · 2009 to 2011
$1.6M
NCATS NIH HHS T32 TR000002NCATS NIH HHS UL1 TR000002NCRR NIH HHS R24 RR025871NCRR NIH HHS RR025871
6 · The paper itself

Abstract

Tuberculosis (TB) pathologic lesions in rhesus macaques resemble those in humans. The expression levels of several host TB candidate genes in the peripheral blood mononuclear cells (PBMCs) of six rhesus macaques experimentally infected with Mycobacterium tuberculosis were quantified pre-infection and at several dates post-infection. Quantitative measures of TB histopathology in the lungs including: granuloma count, granuloma size, volume of granulomatous and non-granulomatous lesions, and direct bacterial load, were used as the outcomes of a multi-level Bayesian regression model in which expression levels of host genes at various dates were used as predictors. The results indicate that the expression levels of TR4, CD40, CD40L, FAS (CD95) and TNF in PBMC were associated with quantitative measures of the severity of TB histopathologic lesions in the lungs of the study animals. Moreover, no reliable association between the expression levels of IFNE in PBMCs and the severity of TB lesions in the lungs of the study animals was found. In conclusion, PBMC expression profiles derived from the above-listed host genes might be appropriate biomarkers for probabilistic diagnosis and/or prognosis of TB severity in rhesus macaques.

Indexed as

Gene ExpressionGenetic Predisposition to DiseaseMycobacterium tuberculosisAnimalsCD40 AntigensCD40 LigandCluster Analysisfas ReceptorGene Expression ProfilingGenetic Association StudiesGenetic MarkersHost-Pathogen InteractionsLeukocytes, MononuclearLungMacaca mulattaMonkey DiseasesCD40 AntigensCD40 Ligandfas ReceptorGenetic MarkersReceptors, Thyroid HormoneTumor Necrosis FactorsGene expressionHistopathologic lesionsHost genesIFNERhesus macaquesTR4Tuberculosis (TB)

Identifiers

PMID26483316
PMCPMC9924821
OpenAlexW1778680806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.