SynthesisActa veterinaria Scandinavica2015
C-reactive protein: quantitative marker of surgical trauma and post-surgical complications in dogs: a systematic review.
Synthesis in Acta veterinaria Scandinavica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Changes of Serum Procalcitonin (PCT), C-Reactive Protein (CRP), Interleukin-17 (IL-17), Interleukin-6 (IL-6), High Mobility Group Protein-B1 (HMGB1) and D-Dimer in Patients with Severe Acute Pancreatitis Treated with Continuous Renal Replacement Therapy (CRRT) and Its Clinical Significance.Medical science monitor : international medical journal of experimental and clinical research · 2018Trial
- Presumptive Postoperative Nontraumatic Adrenal Haemorrhage After Orthopaedic Surgery in a Dog.Veterinary medicine and science · 2026Article
- Postoperative kinetics of point-of-care C-reactive protein versus total white blood cell count after tibial plateau leveling osteotomy in dogs.Veterinary world · 2026Article
- Impact of combined unilateral mastectomy and ovariohysterectomy on acute phase response and wound healing in dogs with mammary gland tumors.BMC veterinary research · 2026Article
- Acute endocrine responses to snouted cobra (Naja annulifera) and African puffadder (Bitis arietans) envenomation in dogs.Journal of veterinary internal medicine · 2026Article
- Pilot Study: Association Between Surgical Severity and Postoperative Point-of-Care C-Reactive Protein Levels in Dogs Undergoing Orthopedic Surgery.Veterinary sciences · 2025Article
- Analytical comparison of three canine C-reactive protein assays in clinical use in Japan.The Journal of veterinary medical science · 2025Article
- Comparison of outcomes between laparotomic and laparoscopic elective ovariectomy in anestrus dogs: postoperative recovery, pain and inflammatory biomarkers.Veterinary research communications · 2025Article
- Pentoxifylline in Dogs With Osteoarthritis: Comparative Treatment and Efficacy Analysis With Meloxicam.Veterinary medicine and science · 2025Article
- Comparison of surgical invasiveness between micro-endoscopic discectomy/microscopic discectomy and conventional hemilaminectomy in dogs.The Journal of veterinary medical science · 2023Article
- Inflammatory biomarker concentrations in dogs with gastric dilatation volvulus with and without 24-h intravenous lidocaine.Frontiers in veterinary science · 2023Article
- Instrument shank-assisted ovariohysterectomy: a randomized clinical trial of surgical and pain alleviation efficiency of a single-person modified technique.Frontiers in veterinary science · 2023Article
- Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- C-Reactive Protein as a Diagnostic Marker in Dogs: A Review.Animals : an open access journal from MDPI · 2022Review
- Augmentation cystoplasty in dogs: A comparative study of different tunica vaginalis grafts.Veterinary and animal science · 2022Article
- Serum C-reactive protein and iron levels following gonadectomy are not modified by perioperative administration of robenacoxib to dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Kinetics of Plasma Cytokines, Angiopoietin-2, and C-Reactive Protein in Dogs With Gastric Dilatation Volvulus.Frontiers in veterinary science · 2021Article
- Changes in Acute Phase Proteins in Bitches after Laparoscopic, Midline, and Flank Ovariectomy Using the Same Method for Hemostasis.Animals : an open access journal from MDPI · 2020Article
- Extremely high canine C-reactive protein concentrations > 100 mg/l - prevalence, etiology and prognostic significance.BMC veterinary research · 2020Article
- Characterization of C-reactive protein in dogs undergoing medial patellar luxation surgery.PloS one · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-reactive protein (CRP) is a major acute phase protein showing increasing serum concentrations in dogs with systemic inflammation following e.g., surgery, trauma, infections, or neoplasia. CRP is a useful diagnostic marker of systemic inflammation in dogs and automated assays have been validated for reliable measurements for routine diagnostic purposes. In the present study available evidence for the use of CRP as a marker of surgery related systemic inflammation in dogs was reviewed and assessed. Two main themes were in focus: (1) canine CRP as a potential marker of postsurgical infectious complications and (2) canine CRP as a marker of the degree of surgical trauma. As outlined in the review several studies suggest that CRP is a useful marker for both purposes. However, the evidence level is limited and studies in the field are all affected by considerable risks of bias. Thus, further studies are needed in order to confirm the assumptions from previous studies and increase the level of evidence for CRP as a useful marker for detecting inflammation after surgery in dogs.
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