Evidence map›Paper›PMID 26482993›Full record

ArticleJournal of vascular surgery2016

Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice.

Osama M El-Sayed, Nicholas A Dewyer, Catherine E Luke, Megan Elfline, Adriana Laser, Cory Hogaboam, Steven L Kunkel, Peter K Henke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Immune cell-mediated venous thrombus resolution.Research and practice in thrombosis and haemostasis · 2023
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. The role of bone marrow-derived cells in venous thromboembolism.The international journal of biochemistry & cell biology · 2020
    Review
  13. Model-dependent contributions of FXII and FXI to venous thrombosis in mice.Journal of thrombosis and haemostasis : JTH · 2020
    Article
  14. The effect of anesthetics on toll like receptor 9.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  15. B cell-intrinsic TLR9 expression is protective in murine lupus.The Journal of clinical investigation · 2020
    Article
  16. Resolution of Deep Venous Thrombosis: Proposed Immune Paradigms.International journal of molecular sciences · 2020
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Osama M El-SayedDepartment of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Mich.
Nicholas A DewyerDepartment of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Mich.
Catherine E LukeDepartment of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Mich.
Megan ElflineDepartment of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Mich.
Adriana LaserDepartment of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Mich.
Cory HogaboamDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Mich.
Steven L KunkelDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Mich.
Peter K HenkeDepartment of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Mich. Electronic address: henke@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Cytokine-induced epigenetic changes during chronic lung diseaseR01HL112897 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DOU, YALI, KUNKEL, STEVEN LYNN · 2013 to 2016
$2.2M
Vein Wall Fibrotic Injury After DVT is SLC-CCR7 DependentR01HL092129 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K · 2009 to 2012
$1.5M
NHLBI NIH HHS R01 HL092129NHLBI NIH HHS R01 HL112897
6 · The paper itself

Abstract

backgroundDeletion of Toll-like receptor 9 (Tlr9) signaling, which is important for sterile inflammatory processes, results in impaired resolution of venous thrombosis (VT) in mice. The purpose of this study was to determine if deletion of Tlr9 affected sterile necrosis, apoptosis, and neutrophil extracellular trap (NET) production in VT.

methodsStasis and nonstasis murine models of VT were used in wild-type (WT) and Tlr9

resultsAt 2 days, stasis thrombi in Tlr9

conclusionsThese data suggest that the thrombogenic model affects Tlr9 thrombogenic mechanisms and that functional Tlr9 signaling in PMNs, but not in platelets or NETs, is an important mechanism in early stasis experimental venous thrombogenesis.

Indexed as

Blood CoagulationAnimalsApoptosisBiomarkersDeoxyribonuclease IDisease Models, AnimalExtracellular TrapsGenotypeHydrolasesMaleMice, Inbred BALB CMice, KnockoutNecrosisNeutrophilsPhenotypeProtein-Arginine Deiminase Type 4BiomarkersDeoxyribonuclease IHydrolasespeptidylarginine deiminase 4, mouseProtein-Arginine Deiminase Type 4Tlr9 protein, mouseToll-Like Receptor 9

Identifiers

PMID26482993
PMCPMC4834067
OpenAlexW2154649516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.