Evidence map›Paper›PMID 26482776›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma.

Chuan Jin, Bingchuan Yan, Qin Lu, Yanmin Lin, Lei Ma

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Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chuan JinDepartment of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical University, Guangzhou, China.
Bingchuan YanDepartment of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical University, Guangzhou, China.
Qin LuDepartment of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical University, Guangzhou, China.
Yanmin LinOncology Center, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.
Lei MaDepartment of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical University, Guangzhou, China. leima_01@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies demonstrated that long non-coding RNAs (lncRNAs) have a critical role in the regulation of cancer progression and metastasis. However, little is known whether lncRNA regulated nasopharyngeal carcinoma (NPC) cell radioresistance. In the present study, we found that MALAT1 was significantly upregulated in NPC cell lines and tissues. Knockdown of MALAT1 could sensitize NPC cells to radiation both in vitro and in vivo. Interestingly, we found that MALAT1 regulated radioresistance by modulating cancer stem cell (CSC) activity. Furthermore, we found that there was reciprocal repression between MALAT1 and miR-1, and slug was identified as a downstream target of miR-1. Taking these observations into consideration, we proposed that MALAT1 regulated CSC activity and radioresistance by modulating miR-1/slug axis, which indicated that MALAT1 could act as a therapeutic target for NPC patients.

Indexed as

AnimalsBase SequenceBinding SitesCell Line, TumorFemaleGene ExpressionGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMice, NudeMicroRNAsMiddle AgedNasopharyngeal NeoplasmsNeoplasm TransplantationRadiation ToleranceMALAT1 long non-coding RNA, humanMicroRNAsMIRN1 microRNA, humanRNA, Long NoncodingSNAI1 protein, humanSnail Family Transcription FactorsMALAT1miR-1RadioresistanceSlug

Identifiers

PMID26482776

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.