ArticleNanoscale2015
Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film.
Article in Nanoscale, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Physico-chemically different carbon nanomaterials may elicit similar inflammatory molecular pathways within the lungs of mice.Toxicology research · 2025Article
- Molecular basis of transport of surface functionalised gold nanoparticles to pulmonary surfactant.RSC advances · 2022Article
- Prospective pathways of green graphene-based lab-on-chip devices: the pursuit toward sustainability.Mikrochimica acta · 2022Review
- Competitive and/or cooperative interactions of graphene-family materials and benzo[a]pyrene with pulmonary surfactant: a computational and experimental study.Particle and fibre toxicology · 2021Article
- Review
- Direct and Indirect Genotoxicity of Graphene Family Nanomaterials on DNA-A Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Synthesis and Toxicity of Graphene Oxide Nanoparticles: A Literature Review ofBioMed research international · 2021Review
- Toxicology data of graphene-family nanomaterials: an update.Archives of toxicology · 2020Review
- Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale.Particle and fibre toxicology · 2020Review
- Nanoparticle-Based Devices in the Control of Antibiotic Resistant Bacteria.Frontiers in microbiology · 2020Review
- The LLangmuir : the ACS journal of surfaces and colloids · 2018Article
- Electronic cigarette vapor alters the lateral structure but not tensiometric properties of calf lung surfactant.Respiratory research · 2017Article
- Bulk Heterojunction Morphologies with Atomistic Resolution from Coarse-Grain Solvent Evaporation Simulations.Journal of the American Chemical Society · 2017Article
- Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms.Particle and fibre toxicology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Graphene oxide (GO) is the most common derivative of graphene and has been used in a large range of biomedical applications. Despite considerable progress in understanding its cytotoxicity, its potential inhalation toxicity is still largely unknown. As the pulmonary surfactant (PS) film is the first line of host defense, interaction with the PS film determines the fate of the inhaled nanomaterials and their potential toxicity. Using a coarse-grained molecular dynamics model, we reported, for the first time, a novel mechanism of toxicity caused by the inhaled GO nanosheets. Upon deposition, the GO nanosheets induce pores in the PS film and thus have adverse effects on the ultrastructure and biophysical properties of the PS film. Notably, the pores induced by GO nanosheets result in increasing the compressibility of the PS film, which is an important indication of surfactant inhibition. In vitro experiments have also been conducted to study the interactions between GO and animal-derived natural PS films, qualitatively confirming the simulation results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.