Trial reportThe journal of nutrition, health & aging2015
Effects of Changes in Regional Body Composition on Physical Function in Older Adults: A Pilot Randomized Controlled Trial.
Trial report in The journal of nutrition, health & aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: a systematic review.Aging clinical and experimental research · 2025Pooled it
- Long Term Weight Loss Diets and Obesity Indices: Results of a Network Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- [Obesity in old age and its importance for functionality and frailty].Zeitschrift fur Gerontologie und Geriatrie · 2016Pooled it
- Effect of Aerobic or Resistance Exercise, or Both, on Intermuscular and Visceral Fat and Physical and Metabolic Function in Older Adults With Obesity While Dieting.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Anti-inflammatory drug and prebiotics alter metabolic inflammation in fattening ground squirrels and outbred mice.Frontiers in physiology · 2026Article
- Hidden Hunger in Pediatric Obesity: Redefining Malnutrition Through Macronutrient Quality and Micronutrient Deficiency.Nutrients · 2025Review
- The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act.Obesity (Silver Spring, Md.) · 2025Review
- Exercise and dietary recommendations to preserve musculoskeletal health during weight loss in adults with obesity: A practical guide.Reviews in endocrine & metabolic disorders · 2025Review
- The effects of myosteatosis on skeletal muscle function in older adults.Physiological reports · 2024Review
- Incidence of a Multicomponent Physical Exercise Program on Body Composition in Overweight or Obese People Aged 60 Years or Older from Chile.Journal of functional morphology and kinesiology · 2024Article
- The usefulness of Integrative Neuromuscular Training to counteract obesity: a narrative review.International journal of obesity (2005) · 2024Review
- Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Intermuscular adipose tissue in metabolic disease.Nature reviews. Endocrinology · 2023Review
- Thigh and Calf Myosteatosis are Strongly Associated with Muscle and Physical Function in African Caribbean Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Clinical Features and Body Composition in Men with Hormone-Sensitive Metastatic Prostate Cancer: A Pilot Study Examining Differences by Race.Prostate cancer · 2022Article
- The relationship of alpha-synuclein to mitochondrial dynamics and quality control.Frontiers in molecular neuroscience · 2022Review
- Myosteatosis at diagnosis is adversely associated with 2-year survival in women with estrogen receptor-negative metastatic breast cancer.Breast cancer research and treatment · 2021Article
- Association of Low Muscle Density With Deteriorations in Muscle Strength and Physical Functioning in Rheumatoid Arthritis.Arthritis care & research · 2021Article
- Validation of a description of sarcopenic obesity defined as excess adiposity and low lean mass relative to adiposity.Journal of cachexia, sarcopenia and muscle · 2020Article
- Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectiveObesity exacerbates age-related physical disability; however, observational studies show that any weight loss in old age is associated with greater risk of mortality. Conversely, randomized controlled trials in older adults show that weight loss is beneficial. The discrepancy may be due to weight loss intention and differential changes to regional body composition. The purpose of this research was to evaluate the independent role of regional body composition remodeling in improving physical function.
designPilot Randomized Controlled Trial.
settingCommunity based research center.
participantsThirty-six community dwelling, overweight to moderately obese (BMI 28.0-39.9 kg/m2) older adults (age 70.6±6.1 yrs).
interventionPhysical activity plus weight loss (PA+WL, n=21) or PA plus successful aging (SA) education. PA consisted primary of treadmill walking supplemented with lower extremity resistance and balance training. The WL program was based on the Diabetes Prevention Project and aimed at achieving a 7% weight loss by cutting calories, specifically those from fat. MEASUREMENTS: At baseline, 6- and 12-months, body composition was measured using computerized tomography and dual x-ray absorptiometry. Abdominal visceral (VAT) and thigh intermuscular (IMAT) adipose tissue were quantified. Physical function was assessed using the short physical performance battery (SPPB).
resultsSeparate multivariable linear regression models with both groups combined demonstrated that decreases in IMAT and VAT were significantly associated with improvements in SPPB (P<0.05) independent of change in total fat mass. PA+WL improved SPPB scores from baseline (0.8±1.4, P<0.05), whereas PA+SA did not; however no intergroup difference was detected. Of note, these effects were mainly achieved during the intensive intervention phase.
conclusionDecreases in IMAT and VAT are important mechanisms underlying improved function following intentional weight loss plus physical activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.