Evidence map›Paper›PMID 26482384›Full record

Trial reportJournal of cancer survivorship : research and practice2016

The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial.

James L Devin, Andrew T Sax, Gareth I Hughes, David G Jenkins, Joanne F Aitken, Suzanne K Chambers, Jeffrey C Dunn, Kate A Bolam, Tina L Skinner

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of cancer survivorship : research and practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 69 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 24 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03308734 nawithdrawnnot on this mapstarted 2019, after this paper: background citation

Effects of 6 Week Reduced Exertion High Intensity Interval Training Protocol in Patients With Prostate Cancer

TypeinterventionalSponsorUniversity of BathRan2019 to 2020Enrolled0ConditionsProstate CancerArmsReduced-Exertion High-Intensity Interval Training
NCT04679233 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy

TypeinterventionalSponsorVanderbilt UniversityRan2021 to 2021Enrolled0ConditionsHead and Neck Neoplasm, RadiotherapyArmsPrescription aerobic exercise
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 24 syntheses or guidelines pooled it, 116 citations in OpenAlex.

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  2. Impact of exercise interventions on cardiorespiratory fitness in childhood cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  4. Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
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  7. Effect of home-based exercise prehabilitation on postoperative outcomes in colorectal cancer surgery: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  9. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
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  12. Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

James L DevinSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia. j.devin@uq.edu.au.
Andrew T SaxSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
Gareth I HughesSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
David G JenkinsSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
Joanne F AitkenMenzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.
Suzanne K ChambersMenzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.
Jeffrey C DunnMenzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.
Kate A BolamSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
Tina L SkinnerSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
University of Queensland · AUCancer Council Queensland · AUEdith Cowan University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFollowing colorectal cancer diagnosis and anti-cancer therapy, declines in cardiorespiratory fitness and body composition lead to significant increases in morbidity and mortality. There is increasing interest within the field of exercise oncology surrounding potential strategies to remediate these adverse outcomes. This study compared 4 weeks of moderate-intensity exercise (MIE) and high-intensity exercise (HIE) training on peak oxygen consumption (V̇O2peak) and body composition in colorectal cancer survivors.

methodsForty seven post-treatment colorectal cancer survivors (HIE = 27 months post-treatment; MIE = 38 months post-treatment) were randomised to either HIE [85-95 % peak heart rate (HRpeak)] or MIE (70 % HRpeak) in equivalence with current physical activity guidelines and completed 12 training sessions over 4 weeks.

resultsHIE was superior to MIE in improving absolute (p = 0.016) and relative (p = 0.021) V̇O2peak. Absolute (+0.28 L.min(-1), p < 0.001) and relative (+3.5 ml.kg(-1).min(-1), p < 0.001) V̇O2 peak were increased in the HIE group but not the MIE group following training. HIE led to significant increases in lean mass (+0.72 kg, p = 0.002) and decreases in fat mass (-0.74 kg, p < 0.001) and fat percentage (-1.0 %, p < 0.001), whereas no changes were observed for the MIE group. There were no severe adverse events.

conclusionsIn response to short-term training, HIE is a safe, feasible and efficacious intervention that offers clinically meaningful improvements in cardiorespiratory fitness and body composition for colorectal cancer survivors. IMPLICATIONS FOR CANCER SURVIVORS: HIE appears to offer superior improvements in cardiorespiratory fitness and body composition in comparison to current physical activity recommendations for colorectal cancer survivors and therefore may be an effective clinical utility following treatment.

Indexed as

Cardiorespiratory FitnessSurvivorsAdultAgedBody CompositionColorectal NeoplasmsExerciseExercise TherapyFemaleHeart RateHumansMaleMiddle AgedOxygen ConsumptionPhysical FitnessBody composition [MESH]Cardiorespiratory fitnessColorectal cancer [MESH]Exercise [MESH]Exercise oncologyHigh-intensity exercise

Identifiers

PMID26482384
OpenAlexW1864731096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.