Evidence map›Paper›PMID 26482255›Full record

ArticlePediatric nephrology (Berlin, Germany)2016

Urinary fibrogenic cytokines ET-1 and TGF-β1 are associated with urinary angiotensinogen levels in obese children.

Liane Correia-Costa, Manuela Morato, Teresa Sousa, Dina Cosme, João Tiago Guimarães, António Guerra, Franz Schaefer, Alberto Caldas Afonso, Ana Azevedo, António Albino-Teixeira

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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Chronic kidney disease combined with metabolic syndrome is a non-negligible risk factor.Therapeutic advances in endocrinology and metabolism · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Liane Correia-CostaEpidemiology Research Unit (EPIUnit), Institute of Public Health, University of Porto, Rua das Taipas, nº 135, 4050-600, Porto, Portugal. liane@med.up.pt.
Manuela MoratoDepartment of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
Teresa SousaDepartment of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
Dina CosmeEpidemiology Research Unit (EPIUnit), Institute of Public Health, University of Porto, Rua das Taipas, nº 135, 4050-600, Porto, Portugal.
João Tiago GuimarãesEpidemiology Research Unit (EPIUnit), Institute of Public Health, University of Porto, Rua das Taipas, nº 135, 4050-600, Porto, Portugal.
António GuerraDepartment of Pediatrics, Faculty of Medicine, University of Porto, Porto, Portugal.
Franz SchaeferDivision of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany.
Alberto Caldas AfonsoEpidemiology Research Unit (EPIUnit), Institute of Public Health, University of Porto, Rua das Taipas, nº 135, 4050-600, Porto, Portugal.
Ana AzevedoEpidemiology Research Unit (EPIUnit), Institute of Public Health, University of Porto, Rua das Taipas, nº 135, 4050-600, Porto, Portugal.
António Albino-TeixeiraDepartment of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
Universidade do Porto · PTUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFibrogenic cytokines are recognized as putative drivers of disease activity and histopathological deterioration in various kidney diseases. We compared urinary transforming growth factor β1 (U-TGF-β1) and endothelin 1 (U-ET-1) levels across body mass index classes and assessed their association with the level of urinary angiotensinogen (U-AGT), a biomarker of intrarenal renin-angiotensin-aldosterone system (RAAS).

methodsThe was a cross-sectional evaluation of 302 children aged 8-9 years. Ambulatory blood pressure (BP), insulin resistance (HOMA-IR), aldosterone level and renal function were evaluated. U-ET-1, U-TGF-β1 and U-AGT levels were determined by immunoenzymatic methods.

resultsObese children presented with the lowest levels of U-ET-1 and U-TGF-β1, but the difference was only significant for U-ET-1. In obese children, the median levels of both U-ET-1 and U-TGF-β1 tended to increase across tertiles (T1-T3) of U-AGT (U-ET-1: T1, 19.9 (14.2-26.3); T2, 32.5 (23.3-141.6); T3, 24.8 (18.7-51.5) ng/g creatinine, p = 0.007; U-TGF-β1: T1, 2.2 (1.8-4.0); T2, 4.3 (2.7-11.7); T3, 4.9 (3.8-10.1) ng/g creatinine, p = 0.004]. In multivariate models, in the obese group, U-ET-1 was associated with HOMA-IR and aldosterone and U-AGT levels, and U-TGF-β1 was associated with U-AGT levels and 24 h-systolic BP.

conclusionsWhereas the initial hypothesis of higher levels of urinary fibrogenic cytokines in obese children was not confirmed in our study, both TGF-β1 and U-ET-1 levels were associated with U-AGT level, which likely reflects an early interplay between tissue remodeling and RAAS in obesity-related kidney injury.

Indexed as

AdolescentAge FactorsAngiotensinogenBiomarkersBody Mass IndexChildCross-Sectional StudiesEndothelin-1FemaleHumansMalePediatric ObesityRenin-Angiotensin SystemTransforming Growth Factor beta1UrinalysisAGT protein, humanAngiotensinogenBiomarkersEndothelin-1TGFB1 protein, humanTransforming Growth Factor beta1AngiotensinogenChildhood obesityEndothelin-1Kidney injuryTransforming growth factor-β1Urinary biomarkers

Identifiers

PMID26482255
OpenAlexW1887010374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.