Evidence map›Paper›PMID 26482153›Full record

ArticleNeurochemical research2016

In Vitro Metabolomic Approach to Hippocampal Neurodegeneration Induced by Trimethyltin.

Zdenka Gasparova, Nada Pronayova, Veronika Stara, Tibor Liptaj

Abstract read
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In one paragraph

Article in Neurochemical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zdenka GasparovaInstitute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia. zdenka.gasparova@savba.sk.
Nada PronayovaDepartment of NMR and Mass Spectroscopy, Faculty of Food and Chemical Technology, Slovak University of Technology, Bratislava, Slovakia.
Veronika StaraInstitute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia.
Tibor LiptajDepartment of NMR and Mass Spectroscopy, Faculty of Food and Chemical Technology, Slovak University of Technology, Bratislava, Slovakia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Search for indicators of neurodegenerative disorders is a hot topic where much research remains to be done. Our aim was to determine proton nuclear magnetic resonance ((1)H-NMR) spectra of brain metabolites in the trimethyltin (TMT) model of neurodegeneration. Male Wistar rats were subjected to TMT or saline and were sacrificed on day 3 or 24 after administration. (1)H-NMR spectrum was measured on the 600 MHz Varian VNMRS spectrometer in nano-probe in the volume of 40 μl of hippocampal extracts. TMT administration resulted in reduction of the hippocampal weight on day 24. Of the sixteen identified metabolite spectra, decreased aspartate and increased glutamine contents were observed in the initial asymptomatic stage of neurodegeneration on day 3 in hippocampal extracts of TMT exposed rats compared to sham animals. Increased myo-inositol content was observed on day 24. The presented data provide further knowledge about this experimental model and putative indicators of neuronal damage.

Indexed as

MetabolomeTrimethyltin CompoundsAnimalsHippocampusMaleNerve DegenerationOrgan SizeRats, WistartrimethyltinTrimethyltin CompoundsAlzheimer diseaseHippocampusIn vitro 1H-NMR spectroscopyPerchloric acid extractsRatTrimethyltin model of neurodegeneration

Identifiers

PMID26482153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.