Evidence map›Paper›PMID 26481973›Full record

ReviewSeminars in cell & developmental biology2016

Cytokinesis: Robust cell shape regulation.

Vasudha Srivastava, Pablo A Iglesias, Douglas N Robinson

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in cell & developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Mechanics and regulation of cytokinetic abscission.Frontiers in cell and developmental biology · 2022
    Review
  4. Towards the Idea of Molecular Brains.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Regulation of the Total Cell Surface Area in DividingFrontiers in cell and developmental biology · 2020
    Article
  9. The Unusual Suspects in Cytokinesis: Fitting the Pieces Together.Frontiers in cell and developmental biology · 2020
    Review
  10. Article
  11. Review
  12. Article
  13. Molecular Mechanism of Cytokinesis.Annual review of biochemistry · 2019
    Review
  14. Review
  15. Article
  16. Regulating cell-cell junctions from A to Z.The Journal of cell biology · 2016
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vasudha SrivastavaDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, United States.
Pablo A IglesiasDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, United States.
Douglas N RobinsonDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, United States. Electronic address: dnr@jhmi.edu.
Johns Hopkins University · US

Funding

The Biochemical Basis for the Mechanics of CytokinesisR01GM066817 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N · 2003 to 2025
$7.3M
Force-sensitive macromolecular cytoskeletal assemblyR01GM109863 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N, ROCK, RONALD S · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM066817NIGMS NIH HHS R01 GM109863
6 · The paper itself

Abstract

Cytokinesis, the final step of cell division, is a great example of robust cell shape regulation. A wide variety of cells ranging from the unicellular Dictyostelium to human cells in tissues proceed through highly similar, stereotypical cell shape changes during cell division. Typically, cells first round up forming a cleavage furrow in the middle, which constricts resulting in the formation of two daughter cells. Tight control of cytokinesis is essential for proper segregation of genetic and cellular materials, and its failure is deleterious to cell viability. Thus, biological systems have developed elaborate mechanisms to ensure high fidelity of cytokinesis, including the existence of multiple biochemical and mechanical pathways regulated through feedback. In this review, we focus on the built-in redundancy of the cytoskeletal machinery that allows cells to divide successfully in a variety of biological and mechanical contexts. Using Dictyostelium cytokinesis as an example, we demonstrate that the crosstalk between biochemical and mechanical signaling through feedback ensures correct assembly and function of the cell division machinery.

Indexed as

Cell ShapeCytokinesisAnimalsBiomechanical PhenomenaFeedback, PhysiologicalHumansModels, BiologicalMyosin Type IIMyosin Type IIActomyosin contractilityCell mechanicsControl systemCytokinesisFeedback

Identifiers

PMID26481973
PMCPMC4837095
OpenAlexW2180068288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.