Evidence map›Paper›PMID 26481668›Full record

ArticleCell metabolism2015

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages.

Yi Zhou, Xueqing Yu, Huimei Chen, Sara Sjöberg, Joséphine Roux, Lijun Zhang, Al-Habib Ivoulsou, Farid Bensaid, Cong-Lin Liu, Jian Liu and 6 more

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 133 citations in OpenAlex.

  1. Trial
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  6. Type 2 Diabetes Mellitus Remission, Dream or Reality? A Narrative Review of Current Evidence and Integrated Care Strategies.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
  7. Article
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  13. The Role ofJournal of clinical medicine · 2024
    Review
  14. Article
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  18. Article
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  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Yi ZhouDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Nephrology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Xueqing YuDepartment of Nephrology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: yuxq@mail.sysu.edu.cn.
Huimei ChenDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Research Institute of Nephrology, Nanjing University School of Medicine, Nanjing 210002, China.
Sara SjöbergDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Joséphine RouxDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Lijun ZhangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Al-Habib IvoulsouDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Farid BensaidDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Cong-Lin LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jian LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Biological Sciences, School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China.
Joan TordjmanINSERM, U 872, Paris, F-75006 France, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris6, UMRS 872, Paris, F-75006 France; Université Paris Descartes, UMRS 872, Paris, F-75006 France.
Karine ClementINSERM, U 872, Paris, F-75006 France, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie-Paris6, UMRS 872, Paris, F-75006 France; Université Paris Descartes, UMRS 872, Paris, F-75006 France.
Chih-Hao LeeDepartment of Genetics and Complex Diseases, School of Public Health, Harvard University, Boston, MA 02115, USA.
Gokhan S HotamisligilDepartment of Genetics and Complex Diseases, School of Public Health, Harvard University, Boston, MA 02115, USA.
Peter LibbyDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Guo-Ping ShiDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: gshi@rics.bwh.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USDélégation Paris 5 · FRHefei University of Technology · CNSorbonne Université · FRSun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

Tissue AnalysesP01HL048743 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 1992 to 2014
$26.3M
Role of mast cells in obesityR01HL060942 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI SHI, GUO-PING · 1999 to 2019
$5.6M
Molecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0M
Role of Mast Cells in AtherosclerosisR01HL081090 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2007 to 2015
$3.3M
Role of a novel IL18 binding protein in atherosclerosisR01HL123568 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2015 to 2018
$1.7M
NHLBI NIH HHS HL080472NHLBI NIH HHS HL123568NHLBI NIH HHS HL48743NHLBI NIH HHS HL60942NHLBI NIH HHS HL81090NHLBI NIH HHS P01 HL048743NHLBI NIH HHS R01 HL060942NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL081090NHLBI NIH HHS R01 HL123568
6 · The paper itself

Abstract

Mast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants MCs toward anti-inflammatory functions. MCs in the white adipose tissue (WAT) of lean humans and mice express negligible leptin. Adoptive transfer of leptin-deficient MCs expanded ex vivo mitigates diet-induced and pre-established obesity and diabetes in mice. Mechanistic studies show that leptin-deficient MCs polarize macrophages from M1 to M2 functions because of impaired cell signaling and an altered balance between pro- and anti-inflammatory cytokines, but do not affect T cell differentiation. Rampant body weight gain in ob/ob mice, a strain that lacks leptin, associates with reduced MC content in WAT. In ob/ob mice, genetic depletion of MCs exacerbates obesity and diabetes, and repopulation of ex vivo expanded ob/ob MCs ameliorates these diseases.

Indexed as

Mast CellsAnimalsDiabetes MellitusHumansLeptinMacrophagesMiceMice, Inbred C57BLMice, ObeseObesityLeptin

Identifiers

PMID26481668
PMCPMC4670585
OpenAlexW2148409194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.