Evidence map›Paper›PMID 26481585›Full record

ArticleBMC cancer2015

A case-control study of sporadic retinoblastoma in relation to maternal health conditions and reproductive factors: a report from the Children's Oncology group.

Julia E Heck, Negar Omidakhsh, Saeedeh Azary, Beate Ritz, Ondine S von Ehrenstein, Greta R Bunin, Arupa Ganguly

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia E HeckDepartment of Epidemiology, Fielding School of Public Health, University of California, 650 Charles E Young Dr, Box 951772, Los Angeles, CA, 90095-1772, USA. jeheck@ucla.edu.
Negar OmidakhshDepartment of Epidemiology, Fielding School of Public Health, University of California, 650 Charles E Young Dr, Box 951772, Los Angeles, CA, 90095-1772, USA. negar.omid@gmail.com.
Saeedeh AzaryDepartment of Epidemiology, Fielding School of Public Health, University of California, 650 Charles E Young Dr, Box 951772, Los Angeles, CA, 90095-1772, USA. sazary@ucla.edu.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, 650 Charles E Young Dr, Box 951772, Los Angeles, CA, 90095-1772, USA. britz@ucla.edu.
Ondine S von EhrensteinDepartment of Community Health Sciences, Fielding School of Public Health, University of California, 650 Charles E Young Dr, Box 951772, Los Angeles, CA, 90095-1772, USA. ovehren@ucla.edu.
Greta R BuninDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, 3535 Market Street, Room 1472, Philadelphia, PA, 19104, USA. gretabunin@gmail.com.
Arupa GangulyDepartment of Genetics, University of Pennsylvania, USA415 Anatomy Chemistry Building, 3620 Hamilton Walk, Philadelphia, PA, 19104, USA. GANGULY@MAIL.MED.UPENN.EDU.

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
Parental genotypes and exposures in sporadic retinoblastomaR01CA118580 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GANGULY, ARUPA · 2007 to 2011
$3.5M
Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323k
Parental Occupation and Childhood CancersR03ES021643 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2012 to 2013
$152k
NCI NIH HHS R01 CA118580NCI NIH HHS R01CA118580NCI NIH HHS R21 CA175959NCI NIH HHS R21CA175959NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NIEHS NIH HHS R03 ES021643NIEHS NIH HHS R03ES021643
6 · The paper itself

Abstract

backgroundThe early age at retinoblastoma occurrence, the most common eye malignancy in childhood, suggests that perinatal factors may contribute to its etiology.

methodsIn a large multicenter study of non-familial retinoblastoma, we conducted structured interviews with the parents of 280 cases and 146 controls to elicit information on health during the perinatal period. We used unconditional logistic regression to assess associations between retinoblastoma and parental fertility treatment, birth control use in the year prior to pregnancy, maternal health conditions and the use of prescription medications during pregnancy, and whether mothers breastfed the index child.

resultsBilateral retinoblastoma was related to maternal underweight (body mass index <18.5) prior to pregnancy [Odds Ratio (OR) = 4.5, 95 % confidence interval (CI) 1.0, 20]. With regards to unilateral retinoblastoma, we observed a negative association with the use of condoms in the year prior to pregnancy (OR = 0.4, CI 0.2, 0.9), and a trend towards a positive association with maternal diabetes (OR = 2.2, CI 0.8, 6.6).

conclusionsResults from our study suggest a role for several maternal health and reproductive factors. Given that there are few epidemiologic studies of retinoblastoma, our results require replication in studies which utilize medical record review.

Indexed as

Maternal HealthPrenatal Exposure Delayed EffectsReproductive HistoryAdultCanadaChild, PreschoolFemaleFertilityHumansIncidenceMaleMaternal AgeOdds RatioPregnancyRetinal NeoplasmsRetinoblastoma

Identifiers

PMID26481585
PMCPMC4615328

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.