ArticleParasitology research2016
Increase number of mitochondrion-like organelle in symptomatic Blastocystis subtype 3 due to metronidazole treatment.
Article in Parasitology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- A Systematic Review about the Efficacy of Antiparasitic Agents in the Treatment of Blastocystis Species.Acta parasitologica · 2025Pooled it
- Antiparasitic activity and molecular docking of canthin-6-one derivatives from LED- modulated Eurycoma longifolia roots against Blastocystis ST3 and ST7.Scientific reports · 2026Article
- Prevalence and Subtypes of Blastocystis in Symptomatic Children in Egypt and Anti-Blastocystis Efficacy of Artemisia alba-Loaded Silver Nanoparticles In Vitro and in Swiss Albino Mice.Acta parasitologica · 2026Article
- Lactobacillus probiotics potential in Blastocystis infection: in vitro and in vivo studies.Gut pathogens · 2025Article
- Assessment of the Therapeutic Role of Allium tuncelianum Extract in Rats Infected with Blastocystis Subtype 3.Acta parasitologica · 2025Article
- The effects of LED Spectra on synthesis of antiparasitic bioactive compound in Eurycoma longifolia hairy root culture against Blastocystis Sp.Scientific reports · 2025Article
- Distinct Phenotypic Variation ofBiology · 2022Article
- Comparison of apoptotic responses in Blastocystis sp. upon treatment with Tongkat Ali and Metronidazole.Scientific reports · 2021Article
- In vitro susceptibility of humanSaudi journal of biological sciences · 2021Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blastocystis sp., an intestinal organism is known to cause diarrhea with metronidazole regarded as the first line of treatment despite reports of its resistance. The conflicting reports of variation in drug treatment have been ascribed to subtype differences. The present study evaluated in vitro responses due to metronidazole on ST3 isolated from three symptomatic and asymptomatic patients, respectively. Symptomatic isolates were obtained from clinical patients who showed symptoms such as diarrhea and abdominal bloating. Asymptomatic isolates from a stool survey carried out in a rural area. These patients had no other pathogens other than Blastocystis. Ultrastructural studies using transmission electron microscopy (TEM) and scanning electron microscopy (SEM) revealed drug-treated ST3 from symptomatic patients were irregular and amoebic with surface showing high-convoluted folding when treated with metronidazole. These organisms had higher number of mitochondrion-like organelle (MLO) with prominent cristae. However, the drug-treated ST3 from asymptomatic persons remained spherical in shape. Asymptomatic ST3 showed increase in the size of its central body with the MLO located at the periphery.
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