ReviewNature reviews. Rheumatology2016
Vitamin D in rheumatoid arthritis-towards clinical application.
Review in Nature reviews. Rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Pooled it
- Serum 25-hydoxyvitamin D concentrations in relation to Hashimoto's thyroiditis: a systematic review, meta-analysis and meta-regression of observational studies.European journal of nutrition · 2020Pooled it
- Pooled it
- The Effects of Vitamin D and Marine Omega-3 Fatty Acid Supplementation on Chronic Knee Pain in Older US Adults: Results From a Randomized Trial.Arthritis & rheumatology (Hoboken, N.J.) · 2020Trial
- Impact of season on the association between vitamin D levels at diagnosis and one-year remission in early Rheumatoid Arthritis.Scientific reports · 2020Trial
- Effects of vitamin D supplements on frequency of CD4European journal of clinical nutrition · 2019Trial
- Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y.The American journal of clinical nutrition · 2017Trial
- Association between patterns of circulating vitamin co-exposure and the prognosis of rheumatoid arthritis.Clinical rheumatology · 2026Article
- Effects of Vitamin D on Epigenetics, Seasonality, and Management of Rheumatoid Arthritis.Nutrients · 2026Review
- Vitamin D Receptor Polymorphisms and Rheumatoid Arthritis Risk: A Systematic Review and Meta-Analysis Evaluating the Moderating Effects of Ethnicity, Bone Erosion, and Classification Criteria.Archives of rheumatology · 2026Article
- The Role of Vitamin D in Autoimmune Diseases.International journal of molecular sciences · 2026Review
- Vitamin D status in patients with arthritis and osteoporosis: a comparative analysis of inpatient and outpatient cohorts.Frontiers in endocrinology · 2026Article
- Article
- Article
- Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis.Heliyon · 2025Review
- The role of vitamin D: a promising pathway to combat neuropsychiatric lupus disorders.Clinical and experimental immunology · 2025Article
- Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review.Cancers · 2024Review
- Review
- In vivo vitamin D targets reveal the upregulation of focal adhesion-related genes in primary immune cells of healthy individuals.Scientific reports · 2024Article
- Vitamin D and Muscle Status in Inflammatory and Autoimmune Rheumatic Diseases: An Update.Nutrients · 2024Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In addition to its well-documented involvement in mineral homeostasis, vitamin D seems to have broad effects on human health that go beyond the skeletal system. Prominent among these so-called nonclassical effects of vitamin D are its immunomodulatory properties. In vitro studies have shown anti-inflammatory effects of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active form of vitamin D. In addition, epidemiological analysis of patients with established inflammatory disease identified associations between vitamin D deficiency (low serum concentrations of inactive 25-hydroxyvitamin D, abbreviated to 25(OH)D) and inflammatory conditions, including rheumatoid arthritis (RA). The association of vitamin D deficiency with RA severity supports the hypothesis of a role for vitamin D in the initiation or progression of the disease, or possibly both. However, whether 25(OH)D status is a cause or consequence of RA is still incompletely understood and requires further analysis in prospective vitamin D supplementation trials. The characterization of factors that promote the transition from preclinical to clinical phases of RA has become a major focus of research, with the aim to facilitate earlier diagnosis and treatment, and improve therapeutic outcomes. In this Review, we aim to describe the current knowledge of vitamin D and the immune system specifically in RA, and discuss the potential benefits that vitamin D might have on slowing RA progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.