Evidence map›Paper›PMID 26481357›Full record

ArticleNucleic acids research2016

WikiPathways: capturing the full diversity of pathway knowledge.

Martina Kutmon, Anders Riutta, Nuno Nunes, Kristina Hanspers, Egon L Willighagen, Anwesha Bohler, Jonathan Mélius, Andra Waagmeester, Sravanthi R Sinha, Ryan Miller and 5 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 242 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
242citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

242 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Oncology research · 2026
    Article
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  19. Uterine fibroids show evidence of shared genetic architecture with blood pressure traits.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025
    Article
  20. EarlyFrontiers in immunology · 2025
    Article

182 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Martina KutmonDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands martina.kutmon@maastrichtuniversity.nl.
Anders RiuttaGladstone Institutes, San Francisco, California, CA 94158, USA.ORCID http://orcid.org/0000-0002-4693-0591
Nuno NunesDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands.
Kristina HanspersGladstone Institutes, San Francisco, California, CA 94158, USA.
Egon L WillighagenDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-7542-0286
Anwesha BohlerDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-7073-5852
Jonathan MéliusDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-8624-2972
Andra WaagmeesterDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands Micelio, Antwerp, 2180 Antwerp, Belgium.ORCID http://orcid.org/0000-0001-9773-4008
Sravanthi R SinhaKeshav Memorial Institute of Technology, Hyderabad, Telangana 500029, India.ORCID http://orcid.org/0000-0002-4503-0401
Ryan MillerDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-3477-7443
Susan L CoortDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-1224-9690
Elisa CirilloDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-0241-7833
Bart SmeetsDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-6370-6965
Chris T EveloDepartment of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands.
Alexander R PicoMaastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, 6229 ER Maastricht, The Netherlands apico@gladstone.ucsf.edu.

Funding

TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
WikiPathways Project: At the Intersection of Big Data and Researcher KnowledgeR01GM100039 · NIGMS · J. DAVID GLADSTONE INSTITUTES · PI PICO, ALEXANDER R · 2012 to 2020
$3.4M
NIGMS NIH HHS GM100039NIGMS NIH HHS GM103504NIGMS NIH HHS P41 GM103504NIGMS NIH HHS R01 GM100039
6 · The paper itself

Abstract

WikiPathways (http://www.wikipathways.org) is an open, collaborative platform for capturing and disseminating models of biological pathways for data visualization and analysis. Since our last NAR update, 4 years ago, WikiPathways has experienced massive growth in content, which continues to be contributed by hundreds of individuals each year. New aspects of the diversity and depth of the collected pathways are described from the perspective of researchers interested in using pathway information in their studies. We provide updates on extensions and services to support pathway analysis and visualization via popular standalone tools, i.e. PathVisio and Cytoscape, web applications and common programming environments. We introduce the Quick Edit feature for pathway authors and curators, in addition to new means of publishing pathways and maintaining custom pathway collections to serve specific research topics and communities. In addition to the latest milestones in our pathway collection and curation effort, we also highlight the latest means to access the content as publishable figures, as standard data files, and as linked data, including bulk and programmatic access.

Indexed as

Databases, ChemicalModels, BiologicalGene Expression ProfilingGenesHumansMetabolomics

Identifiers

PMID26481357
PMCPMC4702772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.