Evidence map›Paper›PMID 26481245›Full record

ReviewVirchows Archiv : an international journal of pathology2016

The heterogeneity of follicular lymphomas: from early development to transformation.

Luc Xerri, Stephan Dirnhofer, Leticia Quintanilla-Martinez, Birgitta Sander, John K C Chan, Elias Campo, Steven H Swerdlow, German Ott

Abstract readReview
PubMed Publisher
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. B-cell lymphomas with discordance between pathological features and clinical behavior.Virchows Archiv : an international journal of pathology · 2017
    Article
  12. Understanding the New WHO Classification of Lymphoid Malignancies: Why It's Important and How It Will Affect Practice.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 7 countries.

Luc XerriDepartment of Bio-Pathology, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France. xerril@ipc.unicancer.fr.
Stephan DirnhoferInstitute of Pathology, University Hospital Basel, Basel, Switzerland.
Leticia Quintanilla-MartinezInstitute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.
Birgitta SanderDepartment of Laboratory Medicine, Division of Pathology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden.
John K C ChanQueen Elizabeth Hospital, Hong Kong, SAR, China.
Elias CampoHospital Clinic, University of Barcelona, Barcelona, Spain.
Steven H SwerdlowDivision of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
German OttDepartment of Clinical Pathology, Robert-Bosch-Hospital and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology · DEInstitut Paoli-Calmettes · FRKarolinska Institutet · SEQueen Elizabeth Hospital · CNUniversitat de Barcelona · ESUniversity Hospital of Basel · CHUniversity of Pittsburgh · USUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follicular lymphoma (FL) is a lymphoma composed of germinal center B cells, i.e., centroblasts and centrocytes, that almost always show at least a focal follicular growth pattern. Most cases have a characteristic CD5-, CD10+, BCL6+, and BCL2+ immunophenotype, and 85 % of cases exhibit the hallmark translocation t(14;18)(q32;q21) involving BCL2 and IGH. Although the typical clinicopathological findings of FL are well recognized, cases with unusual clinical, morphologic, immunophenotypic, and genetic features may pose problems in diagnosis and nomenclature. In the slide workshop organized by the European Association for Haematopathology (EAHP) and the Society for Hematopathology (SH) held in Istanbul, Turkey, unusual variants of FL were discussed based on the submitted cases, including early lesions, localized extranodal presentation, uncommon immunophenotype, rare genetic alterations, diffuse variant, and marginal zone differentiation. Interesting features such as blastoid morphology and unusual progression forms were presented, aiming to understand the genetic basis of transformation. In this report, novel findings and diagnostic challenges emerging from the submitted cases will be highlighted, and new terminologies for some of these lesions are proposed.

Indexed as

ImmunohistochemistryImmunophenotypingAnimalsBiomarkers, TumorB-LymphocytesHumansLymphoma, FollicularTranslocation, GeneticBiomarkers, TumorBCL2ClassificationCytogeneticsFollicular lymphomaImmunohistochemistry

Identifiers

PMID26481245
OpenAlexW2157856132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.