ArticleClinical oral investigations2016
Local, systemic, demographic, and health-related factors influencing pathogenic yeast spectrum and antifungal drug administration frequency in oral candidiasis: a retrospective study.
Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Resistance profiles to antifungal agents in Candida albicans isolated from human oral cavities: systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- The Prevalence and Drug Susceptibility ofAntibiotics (Basel, Switzerland) · 2025Article
- Non-Pharmacological Interventions to Prevent Oropharyngeal Candidiasis in Patients Using Inhaled Corticosteroids: A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- In Vitro Evaluation ofInternational journal of molecular sciences · 2025Article
- Oral Mycobiome Alterations in Postmenopausal Women: Links to Inflammation, Xerostomia, and Systemic Health.Biomedicines · 2024Review
- Impact of changes at theCell surface (Amsterdam, Netherlands) · 2022Article
- Safety and tolerability of cinnamaldehyde in orabase for oral candidiasis treatment: phase I clinical trial.Clinical oral investigations · 2022Article
- Oral Cavity andPathogens (Basel, Switzerland) · 2022Review
- Factors influencing the presence of Candida dubliniensis and other non-albicans species in patients with oral lichen planus: a retrospective observational study.Clinical oral investigations · 2022Observational
- Yeast-Host Interactions:Frontiers in pharmacology · 2021Article
- Risk factors related to oral candidiasis in patients with primary Sjögren's syndrome.Medicina oral, patologia oral y cirugia bucal · 2020Article
- Volatile organic compounds in the breath of oral candidiasis patients: a pilot study.Clinical oral investigations · 2018Article
- The Candida species that are important for the development of atrophic glossitis in xerostomia patients.BMC oral health · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn order to identify oral candidiasis patients being at risk of carrying potentially drug-resistant Candida, the aim of the study was to detect local, systemic, demographic, and health-related factors influencing (I) yeast spectrum composition and (II) antifungal administration frequency. Additionally, the aim was to investigate (III) species shift occurrence. MATERIALS AND
methodsData from 798 patients (496 females, 302 males; mean age 59.7) with oral candidiasis diagnosed based on positive clinical and microbial findings (species identification and CFU count) between 2006 and 2011 were retrospectively analyzed using Pearson's chi(2) test and regression analysis.
resultsAmong 958 isolates, Candida albicans was the most frequently detected (76.8 %). Also, species intrinsically resistant to azoles were frequently isolated (15.8 and 17.7 % of isolates and patients). (I) Infections only caused by C. albicans were significantly associated with the use of inhalation steroids (p = 0.001) and antibiotics (p = 0.04), super-infection of lichen planus (p = 0.002), and the absence of removable dentures (p < 0.001). (II) Anti-mycotics were significantly more frequently administered in patients using inhalation steroids (p = 0.001), suffering from asthma/COPD, or smoking heavily (p = 0.003) and if C. albicans and non-albicans species were detected together (p = 0.001). (III) Pathogen composition did not change over time within the examined period (p = 0.239).
conclusionsDifferent variables enhance the presence of certain Candida and the antifungal prescription frequency. No species shift was evident. CLINICAL RELEVANCE: The major pathogen in oral candidiasis remains C. albicans. Nevertheless, therapeutic problems may be caused by the frequent presence of species intrinsically resistant to azoles, especially in patients wearing dentures.
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