ArticleBioethics2015
Mitochondrial Replacement: Ethics and Identity.
Article in Bioethics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 83 citations in OpenAlex.
- Mitochondrial replacement techniques for treating infertility.Journal of medical ethics · 2026Article
- Mitochondrial DNA Modification in Assisted Reproduction: Concept to Practice-A Narrative Review.International journal of molecular sciences · 2026Review
- An analysis of different concepts of "identity" in the heritable genome editing debate.Medicine, health care, and philosophy · 2024Review
- Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic.Medicine, health care, and philosophy · 2023Article
- Role of abnormal energy metabolism in the progression of chronic kidney disease and drug intervention.Renal failure · 2022Article
- Gene Editing, Identity and Benefit.The Philosophical quarterly · 2022Article
- Mitochondria Related Cell Death Modalities and Disease.Frontiers in cell and developmental biology · 2022Review
- Mitochondrial Replacement Techniques, the Non-Identity Problem, and Genetic Parenthood.Asian bioethics review · 2021Article
- Article
- Prospects of Germline Nuclear Transfer in Women With Diminished Ovarian Reserve.Frontiers in endocrinology · 2021Review
- Human germline editing in the era of CRISPR-Cas: risk and uncertainty, inter-generational responsibility, therapeutic legitimacy.BMC medical ethics · 2020Article
- Can reproductive genetic manipulation save lives?Medicine, health care, and philosophy · 2020Article
- Review
- Revising, Correcting, and Transferring Genes.The American journal of bioethics : AJOB · 2020Article
- Lesbian motherhood and mitochondrial replacement techniques: reproductive freedom and genetic kinship.Journal of medical ethics · 2018Article
- Does egg donation for mitochondrial replacement techniques generate parental responsibilities?Journal of medical ethics · 2018Article
- Mandatory sex selection and mitochondrial transfer.Bioethics · 2018Article
- Genome editing and assisted reproduction: curing embryos, society or prospective parents?Medicine, health care, and philosophy · 2018Article
- Mitochondrial manipulation in fertility clinics: Regulation and responsibility.Reproductive biomedicine & society online · 2018Article
- Should Mitochondrial Donation Be Anonymous?The Journal of medicine and philosophy · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mitochondrial replacement techniques (MRTs) have the potential to allow prospective parents who are at risk of passing on debilitating or even life-threatening mitochondrial disorders to have healthy children to whom they are genetically related. Ethical concerns have however been raised about these techniques. This article focuses on one aspect of the ethical debate, the question of whether there is any moral difference between the two types of MRT proposed: Pronuclear Transfer (PNT) and Maternal Spindle Transfer (MST). It examines how questions of identity impact on the ethical evaluation of each technique and argues that there is an important difference between the two. PNT, it is argued, is a form of therapy based on embryo modification while MST is, instead, an instance of selective reproduction. The article's main ethical conclusion is that, in some circumstances, there is a stronger obligation to use PNT than MST.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.