Trial reportThe American journal of psychiatry2016
Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2-Year Outcomes From the NIMH RAISE Early Treatment Program.
4 registry-linked trialsAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 361 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
361citing papers in PubMed, 10 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
OnTrack>An Online Role-Playing Game for Young People With First Episode Psychosis
OnTrackNY With the Option of Social Network Meetings
Enhancing Evidence-Based Practice for Youth and Emerging Adults With Early Psychosis: Implementation and Evaluation in Diverse Service Settings
Adapting and Improving Transition Care for First Episode Psychosis
Who cites it
361 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews.BMC medicine · 2026Pooled it
- Clinical practice guidelines and quality standards for early intervention in psychosis: an AGREE II appraisal and systematic review of service components.Frontiers in psychiatry · 2026Pooled it
- Treatment effect modifiers of cognitive behaviour therapy in people with psychosis: an individual participant data meta-analysis of RCTs.Health technology assessment (Winchester, England) · 2025Pooled it
- "Short" Versus "Long" Duration of Untreated Psychosis in People with First-Episode Psychosis: A Systematic Review and Meta-Analysis of Baseline Status and Follow-Up Outcomes.Schizophrenia bulletin · 2025Pooled it
- Duration of Untreated Psychosis and Outcomes in First-Episode Psychosis: Systematic Review and Meta-analysis of Early Detection and Intervention Strategies.Schizophrenia bulletin · 2024Pooled it
- Collaborative care approaches for people with severe mental illness.The Cochrane database of systematic reviews · 2024Pooled it
- Impact of employment and income support interventions on the health of young adults with episodic disability: Findings from a systematic review.Scandinavian journal of work, environment & health · 2024Pooled it
- Pathways Through Early Psychosis Care for U.S. Youths From Ethnically and Racially Minoritized Groups: A Systematic Review.Psychiatric services (Washington, D.C.) · 2023Pooled it
- Economic Evaluation of Early Psychosis Interventions From A Canadian Perspective.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022Pooled it
- Resilience Interventions Conducted in Western and Eastern Countries-A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Autonomy Support from Healthcare Professionals Improves Functioning in Early Psychosis Through Psychological Growth.Schizophrenia bulletin · 2026Trial
- Effectiveness of implementing family involvement on patient outcomes in individuals with psychotic disorders: a pragmatic cluster randomised controlled trial.BMC psychiatry · 2025Trial
- Case Study Analysis of a Decision Coaching Intervention for Young Adults with Early Psychosis.Community mental health journal · 2025Trial
- Bipolar Early Intervention Using New Digital Technologies (BLEND): A Pilot Randomised Controlled Trial of a Novel Blended-Digital Early Intervention Model of Care for Youth With Bipolar Disorder I or II.Early intervention in psychiatry · 2025Trial
- The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC).PloS one · 2025Trial
- Examining the Effectiveness of a Digital Media Campaign at Reducing the Duration of Untreated Psychosis in New York State: Results From a Stepped-wedge Randomized Controlled Trial.Schizophrenia bulletin · 2024Trial
- Reliability of Telepsychiatry Assessments Using the Attention-Deficit/Hyperactivity Disorder Rating Scale-IV for Children With Neurodevelopmental Disorders and Their Caregivers: Randomized Feasibility Study.Journal of medical Internet research · 2024Trial
- The impact of early intervention for first episode psychosis on cognitive functioning.Schizophrenia research · 2023Trial
- Predictors of treatment discontinuation during an 18-month multi-site randomized trial of Cognitive Enhancement Therapy for early course schizophrenia.Psychiatry research · 2023Trial
- Gender differences in outcomes of early intervention services for first episode psychosis.Early intervention in psychiatry · 2023Trial
301 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors.
John M KaneFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Delbert G RobinsonFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Nina R SchoolerFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Kim T MueserFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
David L PennFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Robert A RosenheckFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Jean AddingtonFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Mary F BrunetteFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Christoph U CorrellFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Sue E EstroffFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Patricia MarcyFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
James RobinsonFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Piper S Meyer-KalosFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Jennifer D GottliebFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Shirley M GlynnFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
David W LyndeFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Ronny PipesFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Benji T KurianFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Alexander L MillerFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Susan T AzrinFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Amy B GoldsteinFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Joanne B SevereFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Haiqun LinFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Kyaw J SintFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Majnu JohnFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Robert K HeinssenFrom the Division of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, and the Department of Mathematics, Hofstra University, Hempstead, N.Y.; the Feinstein Institute for Medical Research, Manhasset, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Departments of Occupational Therapy, Psychiatry, and Psychology, Center for Psychiatric Rehabilitation, Boston University, Boston; the Departments of Psychology and of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C.; the School of Psychology, Australian Catholic University, Melbourne; the Department of Psychiatry, Yale Medical School, and Yale School of Public Health, New Haven, Conn.; the Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta., Canada; the Geisel School of Medicine, Dartmouth College, Lebanon, N.H.; the Bureau of Behavioral Health, New Hampshire Department of Health and Human Services, Concord, N.H.; Nathan Kline Institute, Orangeburg, N.Y.; Minnesota Center for Chemical and Mental Health, School of Social Work, University of Minnesota, St. Paul; the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Tex.; and the Division of Services and Intervention Research, NIMH, Rockville, Md.
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTrials Operation Unit (OPERATIONS CORE)P30MH090590 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORRELL, CHRISTOPH U · 2010 to 2014
$7.9MNCATS NIH HHS UL1 TR001863NIMH NIH HHS HHSN271200900019CNIMH NIH HHS P30 MH090590NIMH NIH HHS P30MH090590PHS HHS HHSN271200900019C
Abstract
objectiveThe primary aim of this study was to compare the impact of NAVIGATE, a comprehensive, multidisciplinary, team-based treatment approach for first-episode psychosis designed for implementation in the U.S. health care system, with community care on quality of life.
methodThirty-four clinics in 21 states were randomly assigned to NAVIGATE or community care. Diagnosis, duration of untreated psychosis, and clinical outcomes were assessed via live, two-way video by remote, centralized raters masked to study design and treatment. Participants (mean age, 23) with schizophrenia and related disorders and ≤6 months of antipsychotic treatment (N=404) were enrolled and followed for ≥2 years. The primary outcome was the total score of the Heinrichs-Carpenter Quality of Life Scale, a measure that includes sense of purpose, motivation, emotional and social interactions, role functioning, and engagement in regular activities.
resultsThe 223 recipients of NAVIGATE remained in treatment longer, experienced greater improvement in quality of life and psychopathology, and experienced greater involvement in work and school compared with 181 participants in community care. The median duration of untreated psychosis was 74 weeks. NAVIGATE participants with duration of untreated psychosis of <74 weeks had greater improvement in quality of life and psychopathology compared with those with longer duration of untreated psychosis and those in community care. Rates of hospitalization were relatively low compared with other first-episode psychosis clinical trials and did not differ between groups.
conclusionsComprehensive care for first-episode psychosis can be implemented in U.S. community clinics and improves functional and clinical outcomes. Effects are more pronounced for those with shorter duration of untreated psychosis.
Indexed as
Education, SpecialEmployment, SupportedPatient Education as TopicPsychotherapyAdolescentAdultAntipsychotic AgentsCommunity Mental Health ServicesFamilyFemaleHumansMaleNational Institute of Mental Health (U.S.)Patient Care TeamPsychotic DisordersQuality of LifeAntipsychotic Agents
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT03390491ClinicalTrials.gov
NCT03464162ClinicalTrials.gov
NCT03919760ClinicalTrials.gov
NCT07713849ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.