ArticleCancer cell2015
A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis.
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Article in Cancer cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
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Who cites it
75 citing papers in PubMed, 115 citations in OpenAlex.
- Phase II Trial of Alisertib in Combination with Irinotecan and Temozolomide for Patients with Relapsed or Refractory Neuroblastoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Trial
- The PLK4 inhibitor RP-1664 demonstrates potent efficacy in neuroblastoma preclinical models through a dual mechanism of sensitivity.Nature communications · 2026Article
- Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.Cell reports · 2026Article
- Regulation and dysregulation of microRNA - transcription factor axes in differentiation and neuroblastoma.Cellular and molecular life sciences : CMLS · 2025Review
- C1QMolecular cancer · 2025Article
- The role of Lin28A and Lin28B in cancer beyond Let-7.FEBS letters · 2024Review
- Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma.Cell reports. Medicine · 2024Article
- METTL3 as a master regulator of translation in cancer: mechanisms and implications.NAR cancer · 2024Review
- AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis.Cell death & disease · 2024Article
- Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival.Journal of the National Cancer Institute · 2024Article
- Investigation of differentially expressed genes related to cellular senescence between high-risk and non-high-risk groups in neuroblastoma.Frontiers in cell and developmental biology · 2024Article
- The survivin-ran inhibitor LLP-3 decreases oxidative phosphorylation, glycolysis and growth of neuroblastoma cells.BMC cancer · 2023Article
- Early Progression of Abdominal Aortic Aneurysm is Decelerated by Improved Endothelial Barrier Function via ALDH2-LIN28B-ELK3 Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- The LIN28B-let-7-PBK pathway is essential for group 3 medulloblastoma tumor growth and survival.Molecular oncology · 2023Article
- Embryonal Tumors of the Central Nervous System with Multilayered Rosettes and Atypical Teratoid/Rhabdoid Tumors.Advances in experimental medicine and biology · 2023Article
- The role of LIN28B in tumor progression and metastasis in solid tumor entities.Oncology research · 2023Review
- LINC00858 stabilizes RAN expression and promotes metastasis of gastric cancer.Biology direct · 2022Article
- miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma.Journal of immunology research · 2022Article
- From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma.Journal of personalized medicine · 2021Review
15 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 4 institutions in 1 country.
Robert W SchneppDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Priya KhuranaDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Edward F AttiyehDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Pichai RamanDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Sara E ChodoshDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Derek A OldridgeDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Maria E GagliardiDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Karina L ConkriteDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Shahab AsgharzadehDivision of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Robert C SeegerDivision of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Blair B MadisonDivision of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Anil K RustgiAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
John M MarisDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: maris@email.chop.edu.
Sharon J DiskinDivision of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: diskin@email.chop.edu.
Children's Hospital of Philadelphia · USChildren's Hospital of Los Angeles · USUniversity of Pennsylvania · USWashington University in St. Louis · US
Funding
CANCER RESEARCH TRAINING PROGRAMT32CA009615 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Gregory L Beatty, MICHAEL D HOGARTY · 1988 to 2026
$10.4MTraining Program in Computational GenomicsT32HG000046 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI JUNHYONG KIM, Mingyao Li · 1999 to 2026
$9.5MPediatric Scholars ProgramK12HD043245 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ST. GEME, JOSEPH W. · 2003 to 2022
$7.4MThe LIN28b-Let7-IMP1 axis in colonic epithelial biologyR01DK056645 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2000 to 2021
$6.8MThe Genetic Basis of Neuroblastoma TumorigenesisR01CA124709 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI MARIS, JOHN M · 2008 to 2017
$6.3MIdentifying Strategies to Increase Engagement in Clinical Trials in Pediatric SCDRC1MD004418 · NIMHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BARAKAT, LAMIA P · 2009 to 2010
$813kCopy number variations (CNVs) in neuroblastomaR00CA151869 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI DISKIN, SHARON · 2012 to 2014
$707kRole of LIN28B in the regulation of intestinal epithelial growthK01DK093885 · NIDDK · WASHINGTON UNIVERSITY · PI MADISON, BLAIR BERNARD · 2012 to 2016
$647kInvestigating non-coding mechanisms of functional dysregulation in neuroblastomaF30CA192831 · NCI · UNIVERSITY OF PENNSYLVANIA · PI OLDRIDGE, DEREK · 2015 to 2016
$57kNCI NIH HHS F30 CA192831NCI NIH HHS R00 CA151869NCI NIH HHS R00-CA151869NCI NIH HHS R01 CA124709NCI NIH HHS R01-CA124709NCI NIH HHS T32 CA009615NHGRI NIH HHS T32 HG000046NICHD NIH HHS K12 HD04324NICHD NIH HHS K12 HD043245NIDDK NIH HHS K01 DK093885NIDDK NIH HHS R01 DK056645NIDDK NIH HHS R01-DK056645NIMHD NIH HHS 1RC1MD004418-01NIMHD NIH HHS RC1 MD004418
Abstract
A more complete understanding of aberrant oncogenic signaling in neuroblastoma, a malignancy of the developing sympathetic nervous system, is paramount to improving patient outcomes. Recently, we identified LIN28B as an oncogenic driver in high-risk neuroblastoma. Here, we identify the oncogene RAN as a LIN28B target and show regional gain of chromosome 12q24 as an additional somatic alteration resulting in increased RAN expression. We show that LIN28B influences RAN expression by promoting RAN Binding Protein 2 expression and by directly binding RAN mRNA. Further, we demonstrate a convergence of LIN28B and RAN signaling on Aurora kinase A activity. Collectively, these findings demonstrate that LIN28B-RAN-AURKA signaling drives neuroblastoma oncogenesis, suggesting that this pathway may be amenable to therapeutic targeting.
Indexed as
Aurora Kinase ABlotting, WesternCarcinogenesisCell Line, TumorChildChromosomes, Human, Pair 12DNA Copy Number VariationsGene AmplificationGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMicroRNAsMolecular ChaperonesNeuroblastomaN-Myc Proto-Oncogene ProteinNuclear Pore Complex ProteinsAURKA protein, humanAurora Kinase ALIN28B protein, humanMicroRNAsmirnlet7 microRNA, humanMolecular ChaperonesMYCN protein, humanN-Myc Proto-Oncogene ProteinNuclear Pore Complex ProteinsNuclear ProteinsOncogene Proteinsran-binding protein 2ran GTP-Binding ProteinRAN protein, humanRNA-Binding Proteins
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