ArticleJournal of the American Geriatrics Society2015
Concordance Between Anticholinergic Burden Scales.
Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review.European journal of clinical pharmacology · 2021Pooled it
- Anticholinergic Burden and Cognitive Performance in Patients With Schizophrenia: A Systematic Literature Review.Frontiers in psychiatry · 2021Pooled it
- Anticholinergic Burden and Fractures: A Systematic Review with Methodological Appraisal.Drugs & aging · 2020Pooled it
- Association between anticholinergic (atropinic) drug exposure and cognitive function in longitudinal studies among individuals over 50 years old: a systematic review.European journal of clinical pharmacology · 2019Pooled it
- Verbal learning deficits associated with increased anticholinergic burden are attenuated with targeted cognitive training in treatment refractory schizophrenia patients.Schizophrenia research · 2019Trial
- Anticholinergic exposure and cognitive decline in older adults: effect of anticholinergic exposure definitions in a 3-year analysis of the multidomain Alzheimer preventive trial (MAPT) study.British journal of clinical pharmacology · 2019Trial
- Optimizing medication appropriateness in older adults: a randomized clinical interventional trial to decrease anticholinergic burden.Alzheimer's research & therapy · 2017Trial
- Anticholinergic medication use and falls in postmenopausal women: findings from the women's health initiative cohort study.BMC geriatrics · 2016Trial
- Differences in Anticholinergic Exposure Assessment Across Burden Scales and Exposure Measures in a Population-Based Study: Implications for Targeted Deprescribing in Older Adults.Drugs & aging · 2026Article
- The Association Between Anticholinergic Burden and Treatment-Related Complications in Older Adults with Cancer.Drugs & aging · 2026Article
- Unveiling the Limits of Anticholinergic Burden Scales: A Study of Adverse Drug Reactions in the French Pharmacovigilance Database.Drug safety · 2026Article
- Anticholinergic burden in community-dwelling older adults: prevalence, associated factors, and agreement between measurement scales.Frontiers in pharmacology · 2026Article
- CALS and ACB Scales are Associated with Physical and Cognitive Impairment and Predict Mortality in Nursing Home Residents.Drugs - real world outcomes · 2025Article
- Polypharmacy and anticholinergic burden scales in older adults: a cross-sectional study among psychiatric outpatients in a tertiary care hospital.BMC geriatrics · 2025Article
- Impact of the Anticholinergic Burden on Disease-Specific Symptoms in Parkinsonian Syndromes.Brain sciences · 2024Article
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- The use of anticholinergic medication is associated with an increased risk of stroke-associated pneumonia.Aging clinical and experimental research · 2022Article
- Anticholinergic Burden, Polypharmacy, and Cognition in Parkinson's Disease Patients with Mild Cognitive Impairment: A Cross-Sectional Observational Study.Dementia and geriatric cognitive disorders · 2022Observational
- Association between anticholinergic burden and dementia in UK Biobank.Alzheimer's & dementia (New York, N. Y.) · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesTo evaluate concordance of five commonly used anticholinergic scales.
designCross-sectional secondary analysis.
settingPittsburgh, Pennsylvania, and Memphis, Tennessee.
participantsCommunity-dwelling adults aged 70 to 79 with baseline medication data from the Health, Aging, and Body Composition Study (N = 3,055). MEASUREMENTS: Any anticholinergic use, weighted scores, and total standardized daily dosage were calculated using five anticholinergic measures (Anticholinergic Cognitive Burden (ACB) Scale, Anticholinergic Drug Scale (ADS), Anticholinergic Risk Scale (ARS), Drug Burden Index anticholinergic component (DBI-ACh), and Summated Anticholinergic Medications Scale (SAMS)). Concordance was evaluated using kappa statistics and Spearman rank correlations.
resultsAny anticholinergic use in rank order was 51% for the ACB, 43% for the ADS, 29% for the DBI-ACh, 23% for the ARS, and 16% for the SAMS. Kappa statistics for all pairwise use comparisons ranged from 0.33 to 0.68. Similarly, concordance as measured using weighted kappa statistics ranged from 0.54 to 0.70 for the three scales not incorporating dosage (ADS, ARS, ACB). Spearman rank correlation between the DBI-ACh and SAMS was 0.50.
conclusionOnly low to moderate concordance was found between the five anticholinergic scales. Future research is needed to examine how these differences in measurement affect their predictive validity with respect to clinically relevant outcomes, such as cognitive impairment.
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