ArticleAge (Dordrecht, Netherlands)2015
Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine.
Article in Age (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Pooled it
- Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- The Benefits of Non-Pharmaceutic Interventions on Intrinsic Capacity in Insulin-Resistant Adult and Geriatric Populations-A Narrative Review.Journal of clinical medicine · 2026Review
- Chronic exercise training intensity, immune cells, and cancer outcomes: a scoping review.JNCI cancer spectrum · 2026Article
- Review
- Natural killer cells from endurance-trained older adults show improved functional and metabolic responses to adrenergic blockade and mTOR inhibition.Scientific reports · 2025Article
- Effect of aging and exercise on hTERT expression in thymus tissue of hTERT transgenic bacterial artificial chromosome mice.GeroScience · 2025Article
- Respiratory Vaccines in Older Adults: A Bibliometric Analysis and Future Research Agenda.Vaccines · 2025Review
- Exercise workload: a key determinant of immune health - a narrative review.Frontiers in immunology · 2025Review
- Immunosenescence, Physical Exercise, and their Implications in Tumor Immunity and Immunotherapy.International journal of biological sciences · 2025Review
- Physical activity and glioblastoma: a paradigm shift in neuro-oncology therapy.Frontiers in oncology · 2025Review
- Article
- Exercise to Prevent Accelerated Vascular Aging in People Living With HIV.Circulation research · 2024Review
- Physical activity and sleep relate to antibody maintenance following naturalistic infection and/or vaccination in older adults.Brain, behavior, & immunity - health · 2023Article
- Can Exercise Enhance the Efficacy of Checkpoint Inhibition by Modulating Anti-Tumor Immunity?Cancers · 2023Review
- Physical activities pre- and post-COVID-19 vaccination and its implementations: A narrative review.SAGE open medicine · 2023Review
- Growing old together: What we know about the influence of diet and exercise on the aging host's gut microbiome.Frontiers in sports and active living · 2023Review
- Body fat percentage is independently and inversely associated with serum antibody responses to SARS-CoV-2 mRNA vaccines.Scientific reports · 2022Article
- DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults.NPJ vaccines · 2022Article
- Impact of Diet and Lifestyle on Vaccine Efficacy in Adults Aged 55 and Older: A Review.Integrative medicine (Encinitas, Calif.) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to verify whether different levels of training performed regularly and voluntarily for many years could have an impact on one of the main issues of immunosenescence: the poor response to vaccines. We recruited 61 healthy elderly men (65-85 years old), 23 with a moderate training (MT) lifestyle (for 17.0 ± 3.2 years), 22 with an intense training (IT) lifestyle (for 25.9 ± 3.4 years), and 16 without a training lifestyle (NT). Fitness was evaluated through the IPAQ and VO2max consumption. The participants were evaluated regarding cognitive aspects, nutritional status, depression, and quality of life. Antibody titers were determined by hemagglutination inhibition assay prior to influenza vaccination and at 6 weeks and 6 months post-vaccination. Strains used were B, H3N2, and H1N1. Our groups were matched for most characteristics, except for those directly influenced by their lifestyles, such as BMI, VO2max, and MET. In general, MT and IT elderly men showed significantly higher antibody titers to the three vaccine strains post-vaccination than NT elderly men. There were also higher titers against B and H1N1 strains in the trained groups before vaccination. Additionally, there were higher proportions of seroprotected (titers ≥1:40) individuals in the pooled trained groups both at 6 weeks (B and H3N2, p < 0.05) and 6 months (H1N1, p < 0.05; B, p = 0.07). There were no significant differences between the MT and IT groups. Either a moderate or an intense training is associated with stronger and longstanding antibody responses to the influenza vaccine, resulting in higher percentages of seroprotected individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.