ArticleCurrent biology : CB2015
Asterless Reduction during Spermiogenesis Is Regulated by Plk4 and Is Essential for Zygote Development in Drosophila.
Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- Molecular models of the sperm head-tail coupling apparatus.Journal of cell science · 2025Review
- Review
- The proximal centriole-like structure maintains nucleus-centriole architecture in sperm.Journal of cell science · 2024Article
- Fly Fam161 is an essential centriole and cilium transition zone protein with unique and diverse cell type-specific localizations.Open biology · 2024Article
- Spermatocytes have the capacity to segregate chromosomes despite centriole duplication failure.EMBO reports · 2024Article
- Structural Analysis of Sperm Centrioles Using N-STORM.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Towards understanding centriole elimination.Open biology · 2023Review
- IgG antibodies label the spermatozoan centriole of Drosophila melanogaster.microPublication biology · 2023Article
- The Centriole's Role in Miscarriages.Frontiers in cell and developmental biology · 2022Article
- Time-lapse imaging of human embryos fertilized with testicular sperm reveals an impact on the first embryonic cell cycle.Biology of reproduction · 2021Article
- The sperm centrioles.Molecular and cellular endocrinology · 2020Review
- Centrioles and Ciliary Structures during Male Gametogenesis in Hexapoda: Discovery of New Models.Cells · 2020Review
- It takes two (centrioles) to tango.Reproduction (Cambridge, England) · 2019Review
- The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis.Results and problems in cell differentiation · 2019Review
- Review
- A novel atypical sperm centriole is functional during human fertilization.Nature communications · 2018Article
- Review
- The Centrioles, Centrosomes, Basal Bodies, and Cilia ofGenetics · 2017Review
- Atypical centrioles are present inOpen biology · 2017Article
- Centriole Remodeling during Spermiogenesis in Drosophila.Current biology : CB · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Centrosome reduction is the decrease in centrosomal components during spermatid differentiation (spermiogenesis). It is one of several dramatic subcellular reorganizations that lead to spermatozoa formation common to a wide range of animals. However, the mechanism underlying centrosome reduction is unknown and its functions are unclear. Here, we show that in Drosophila melanogaster spermiogenesis, the quantity of centrosomal proteins is dramatically reduced; for example, Asterless (Asl) is reduced ∼500-fold and is barely detected in spermatozoa. Asl reduction is regulated through a subset of its domains by the master regulator of centriole duplication Plk4 and by the ubiquitin ligase that targets Plk4 for degradation: Slimb. When Asl reduction is attenuated by Asl overexpression, plk4 mutations, Plk4 RNAi, or Slimb overexpression, Asl levels are higher in spermatozoa, resulting in embryos with reduced viability. Significantly, overexpressing Plk4 and Asl simultaneously, or combining plk4 and slimb mutations, balances their opposing effects on Asl reduction, restoring seemingly normal fertility. This suggests that increased Asl levels cause the observed reduced fertility and not other pleotropic effects. Attenuation of Asl reduction also causes delayed development and a failure to form astral microtubules in the zygote. Together, we provide the first insight into a molecular mechanism that regulates centrosome reduction and the first direct evidence that centrosome reduction is essential for post-fertilization development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.