Observational studyInternational journal of cardiology2016
Clinical epidemiology of heart failure with preserved ejection fraction (HFpEF) in comparatively young hospitalized patients.
Observational study in International journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Adverse Renal Response to Decongestion in the Obese Phenotype of Heart Failure With Preserved Ejection Fraction.Journal of cardiac failure · 2020Trial
- Genetic and Molecular Mechanisms of Non-Ischemic Heart Failure with Preserved Ejection Fraction: Pathway Crosstalk, Translational Implications, and Regional Genetic Context.International journal of molecular sciences · 2026Review
- Characteristics of comparatively young heart failure with preserved ejection fraction: PurSuit-HFpEF registry.Heart and vessels · 2025Article
- Age-stratified profiles and outcomes of patients with heart failure with preserved ejection fraction.ESC heart failure · 2024Article
- Impact of age on characteristics, performance measures and outcomes of inpatients for heart failure in Beijing, China.ESC heart failure · 2023Article
- Obesity, Preserved Ejection Fraction Heart Failure, and Left Ventricular Remodeling.Journal of clinical medicine · 2023Review
- Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study.European heart journal · 2022Article
- p53-Dependent Mitochondrial Compensation in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2022Article
- Age-related alterations in cardiac and arterial structure and function in hypertensive women and men.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Contemporary economic burden in a real-world heart failure population with Commercial and Medicare supplemental plans.Clinical cardiology · 2021Article
- Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure.Clinical science (London, England : 1979) · 2021Review
- Characteristics of Blood Metabolic Profile in Coronary Heart Disease, Dilated Cardiomyopathy and Valvular Heart Disease Induced Heart Failure.Frontiers in cardiovascular medicine · 2020Article
- Exercise Ventilatory Efficiency in Older and Younger Heart Failure Patients With Preserved Ejection Fraction.Journal of cardiac failure · 2019Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWhile heart failure with preserved ejection fraction (HFpEF) is primarily a disease of old age, risk factors that contribute to HFpEF are not limited to older patients. The objectives of this population-based observational study were to describe the clinical epidemiology of HFpEF in younger (<65 years) as compared with older (≥65 years) patients hospitalized with acute decompensated heart failure. METHODS AND
resultsWe reviewed the medical records of residents of central Massachusetts hospitalized with HFpEF at all 11 greater Worcester (MA) medical centers during the 5 study years of 1995, 2000, 2002, 2004, and 2006. Among the 2398 patients hospitalized with confirmed HFpEF, 357 (14.9%) were <65 years old. Younger patients were more likely to be male, non-Caucasian, obese, and to have a history of diabetes and chronic kidney disease than older patients with HFpEF. Younger patients hospitalized with HFpEF were less likely to have received commonly prescribed cardiac medications, had a longer hospital stay, and experienced significantly lower post-discharge death rates than older hospitalized patients.
conclusionWhile HFpEF is predominantly a disease of old age, data from longitudinal studies remain needed to identify risk factors in younger individuals that may predispose them to the development of HFpEF.
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