Evidence map›Paper›PMID 26479580›Full record

ArticleAIDS care2016

Coronary artery disease risk reduction in HIV-infected persons: a comparative analysis.

Nwora Lance Okeke, Tammy Chin, Meredith Clement, Shein-Chung Chow, Charles B Hicks

Abstract read
In one paragraph

Article in AIDS care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Nwora Lance Okekea Division of Infectious Diseases, Department of Medicine , Duke University Medical Center , Durham , NC , USA.
Tammy Chinb School of Medicine , The University of North Carolina , Chapel Hill , NC , USA.
Meredith Clementa Division of Infectious Diseases, Department of Medicine , Duke University Medical Center , Durham , NC , USA.
Shein-Chung Chowc Department of Biostatistics and Bioinformatics , Duke University School of Medicine , Durham , NC , USA.
Charles B Hicksd Division of Infectious Diseases, Department of Medicine , University of California , San Diego , CA , USA.
Duke Medical Center · USDuke University · USUniversity of California, San Diego · USUniversity of North Carolina at Chapel Hill · US

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Ruth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8M
NIAID NIH HHS P30 AI064518NIAID NIH HHS T32 AI007392
6 · The paper itself

Abstract

Despite an increased risk of coronary artery disease (CAD) in persons infected with human immunodeficiency virus (HIV), few data are available on primary prevention of CAD in this population. In this retrospective cohort study, HIV-infected patients treated in an academic medical center HIV Specialty Clinic between 1996 and 2010 were matched by age, gender, and ethnicity to a cohort of presumed uninfected persons followed in an academic medical center Internal Medicine primary care clinic. We compared CAD primary prevention care practices between the two clinics, including use of aspirin, HMG-CoA reductase inhibitors ("statins"), and anti-hypertensive drugs. CAD risk between the two groups was assessed with 10-year Framingham CAD risk scores. In the comparative analysis, 890 HIV-infected persons were compared to 807 controls. Ten-year Framingham CAD Risk Scores were similar in the two groups (median, 3; interquartile range [IQR], 0-5). After adjusting for relevant risk factors, HIV-infected persons were less likely to be prescribed aspirin (odds ratio [OR] 0.53; 95% confidence interval [CI], 0.40-0.71), statins (OR, 0.70; 95% CI, 0.53-0.92), and anti-hypertensive drugs (OR, 0.63; 95% CI, 0.50-0.79) than persons in the control group. In summary, when compared to demographically similar uninfected persons, HIV-infected persons treated in an HIV specialty clinic were less likely to be prescribed medications appropriate for CAD risk reduction. Improving primary preventative CAD care in HIV specialty clinic populations is an important step toward diminishing risk of heart disease in HIV-infected persons.

Indexed as

Practice Patterns, Physicians'AdultAspirinCase-Control StudiesCoronary Artery DiseaseDrug PrescriptionsFemaleHIV InfectionsHumansMaleMiddle AgedOdds RatioRetrospective StudiesRisk FactorsRisk Reduction BehaviorAspirincardiovascular diseaseclinical outcomes researchcoronary artery diseaseHIVprimary care

Identifiers

PMID26479580
PMCPMC4784685
OpenAlexW2229891610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.