ArticleAnimals : an open access journal from MDPI2015
Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows.
Article in Animals : an open access journal from MDPI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Genome-Wide Association Studies of Milk Composition Traits in Holstein Cattle Raised in Tropical and Subtropical Conditions.Animals : an open access journal from MDPI · 2026Article
- Nutritional Regulation of Reproductive Physiology in Ruminants: A Mechanistic Review.Life (Basel, Switzerland) · 2026Review
- Variation in Uterine and Serum Proteins During the Reproductive Cycle in Dairy Cows Following Low and High Dietary Protein Intake.Veterinary medicine and science · 2025Article
- Hematological and serum biochemical profiles at the time of artificial insemination based on pregnancy outcomes in repeat breeder beef cows.Open veterinary journal · 2025Article
- Effect of body condition score loss during the transition period on metabolism, milk yield and health in Holstein cows.Journal of veterinary research · 2025Article
- Selection signatures associated with adaptation in South African Drakensberger, Nguni, and Tuli beef breeds.Tropical animal health and production · 2024Article
- Molecular Mechanisms Associated with the Development of the Metritis Complex in Dairy Cattle.Genes · 2024Article
- Invited Review: Increasing Milk Yield and Negative Energy Balance: A Gordian Knot for Dairy Cows?Animals : an open access journal from MDPI · 2023Review
- Identification of candidate lethal haplotypes and genomic association with post-natal mortality and reproductive traits in Nellore cattle.Scientific reports · 2023Article
- In Vitro Effects of Short-Term and Long-Term Heat Exposures on the Immune Response and Prostaglandin Biosynthesis in Bovine Endometrial Cells.Animals : an open access journal from MDPI · 2022Article
- Effects of dry period length on milk yield and content and metabolic status of high-producing dairy cows under heat stress.Tropical animal health and production · 2021Article
- Comparative biochemical profiles, utero-ovarian function, and fertility of the postpartum buffalo with and without subclinical endometritis.Tropical animal health and production · 2021Article
- Effect of Soybean Oil and Fish Oil on Lipid-Related Transcripts in Subcutaneous Adipose Tissue of Dairy Cows.Animals : an open access journal from MDPI · 2019Article
- Association between milk urea nitrogen and first service conception in smallholder dairy farms under heat and humidity stress.Veterinary world · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Both high and low circulating urea concentrations, a product of protein metabolism, are associated with decreased fertility in dairy cows through poorly defined mechanisms. The rate of involution and the endometrial ability to mount an adequate innate immune response after calving are both critical for subsequent fertility. Study 1 used microarray analysis to identify genes whose endometrial expression 2 weeks postpartum correlated significantly with the mean plasma urea per cow, ranging from 3.2 to 6.6 mmol/L. The biological functions of 781 mapped genes were analysed using Ingenuity Pathway Analysis. These were predominantly associated with tissue turnover (e.g., BRINP1, FOXG1), immune function (e.g., IL17RB, CRISPLD2), inflammation (e.g., C3, SERPINF1, SERPINF2) and lipid metabolism (e.g., SCAP, ACBD5, SLC10A). Study 2 investigated the relationship between urea concentration and expression of 6 candidate genes (S100A8, HSP5A, IGF1R, IL17RB, BRINP1, CRISPLD2) in bovine endometrial cell culture. These were treated with 0, 2.5, 5.0 or 7.5 mmol/L urea, equivalent to low, medium and high circulating values with or without challenge by bacterial lipopolysaccharide (LPS). LPS increased S100A8 expression as expected but urea treatment had no effect on expression of any tested gene. Examination of the genes/pathways involved suggests that plasma urea levels may reflect variations in lipid metabolism. Our results suggest that it is the effects of lipid metabolism rather than the urea concentration which probably alter the rate of involution and innate immune response, in turn influencing subsequent fertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.