SynthesisBMJ clinical evidence2015
Paracetamol (acetaminophen) poisoning.
Synthesis in BMJ clinical evidence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.The Cochrane database of systematic reviews · 2020Pooled it
- Interventions for paracetamol (acetaminophen) overdose.The Cochrane database of systematic reviews · 2018Pooled it
- Paracetamol did not improve the analgesic efficacy with regional block after video assisted thoracoscopic surgery: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Supportive Management of Severe Acetaminophen and Ibuprofen Overdose Twenty-Four Hours After Ingestion in Limited Resources Settings.Journal of medical cases · 2026Article
- Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review).Molecular medicine reports · 2025Review
- Survival Analysis of Liver Transplants in Patients with Acute Liver Failure from Acetaminophen and Mushroom Toxicity.Annals of transplantation · 2025Article
- Laser-induced porous graphene electrodes from polyketimine membranes for paracetamol sensing.Royal Society open science · 2023Article
- Geometric Isomer of Guanabenz Confers Hepatoprotection to a Murine Model of Acetaminophen Toxicity.Chemical research in toxicology · 2023Article
- Estimates of Paracetamol Poisoning in Brazil: Analysis of Official Records From 1990s to 2020.Frontiers in pharmacology · 2022Article
- Notoginsenoside Fc ameliorates renal tubular injury and mitochondrial damage in acetaminophen-induced acute kidney injury partly by regulating SIRT3/SOD2 pathway.Frontiers in medicine · 2022Article
- The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress.Current neuropharmacology · 2021Review
- Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits.Antioxidants (Basel, Switzerland) · 2020Review
- Massive Acetaminophen Overdose.Cureus · 2020Article
- Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury.Stem cell research & therapy · 2020Review
- Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.The lancet. Gastroenterology & hepatology · 2018Article
- [Peppermint oil in the acute treatment of tension-type headache].Schmerz (Berlin, Germany) · 2016Review
- Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19.Science progressObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
introductionParacetamol directly causes around 150 deaths per year in UK. METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of treatments for acute paracetamol poisoning? We searched: Medline, Embase, The Cochrane Library, and other important databases up to October 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview).
resultsAt this update, searching of electronic databases retrieved 127 studies. After deduplication and removal of conference abstracts, 64 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 46 studies and the further review of 18 full publications. Of the 18 full articles evaluated, one systematic review was updated and one RCT was added at this update. In addition, two systematic reviews and three RCTs not meeting our inclusion criteria were added to the Comment sections. We performed a GRADE evaluation for three PICO combinations.
conclusionsIn this systematic overview we categorised the efficacy for six interventions, based on information about the effectiveness and safety of activated charcoal (single or multiple dose), gastric lavage, haemodialysis, liver transplant, methionine, and acetylcysteine.
Indexed as
Identifiers
26479248PMC4610347W1783293645What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.